Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative.

Yasmin H; Das S; Nahar L; Masud MM; Rahman MS; Roy SC; Rahman MM; Gibbons S; Kundu JK; Datta BK; Bachar SC; Chowdhury AK; Sarker SD

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Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative.

机译：6-氟茚满-1-乙酸及其3-氧代衍生物的全合成和止痛活性。

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6-Fluoro-3-oxo-indan-1-acetic acid (5) and 6-fluoroindan-1-acetic acid (6) were conveniently synthesised from 3-fluorobenzaldehyde in four and five steps, respectively. The structures of these new compounds and two other intermediates, 3-fluorobenzylidine-bis-acetoacetate (2) and 3-fluoro-beta-phenyl glutaric acid (3) were elucidated by spectroscopic means, notably, HRMS, 1D and 2D NMR. The analgesic activity of compounds 5 and 6 were assessed by the acetic acid induced writhing in Swiss albino mice.

机译：由3-氟苯甲醛分别通过四个步骤和五个步骤方便地合成了6-氟-3-氧代-茚满-1-乙酸（5）和6-氟茚满-1-乙酸（6）。通过光谱方法，特别是HRMS，1D和2D NMR阐明了这些新化合物和其他两种中间体的结构，即3-氟苄基双乙酰乙酸酯（2）和3-氟-β-苯基戊二酸（3）。通过乙酸诱导的白化病小鼠扭体来评估化合物5和6的镇痛活性。

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《Medicinal chemistry》 |2009年第5期|共6页
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Yasmin H; Das S; Nahar L; Masud MM; Rahman MS; Roy SC; Rahman MM; Gibbons S; Kundu JK; Datta BK; Bachar SC; Chowdhury AK; Sarker SD;
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1. Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative. [J] . Yasmin H, Das S, Nahar L, Medicinal chemistry . 2009,第5期

机译：6-氟茚满-1-乙酸及其3-氧代衍生物的全合成和止痛活性。
2. Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid [J] . Das S, Yasmin H, Masud MM, Tetrahedron . 2008,第37期

机译：6-氟茚满-1-羧酸的全合成和止痛活性
3. Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid [J] . Das S, Yasmin H, Masud MM, Tetrahedron . 2008,第37期

机译：6-氟茚满-1-羧酸的全合成和止痛活性
4. Evaluation of the anti-inflammatory and analgesic activities of the total saponins extracted from fermented Polygala japonica HOUTT [C] . Mingxing Liu, Ting Zhu, Shene Guo, International conference on biotechnology, chemical and materials engineering . 2013

机译：发酵远志HOUTT提取总皂苷的消炎镇痛活性评价
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Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative.

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