Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3-Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3-Carboxylates and their In-Silico Evaluation Against P-falciparum Lactate Dehydrogenase

Rajesh Kancherla; Lavanya Pandian; Iniyavan Pethaperumal; Sarveswari Sundaramoorthy; Ramaiah Sudha; Anbarasu Anand; Vijayakumar Vijayaparthasarathi

首页> 外文期刊>Medicinal chemistry >Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3-Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3-Carboxylates and their In-Silico Evaluation Against P-falciparum Lactate Dehydrogenase

【24h】

Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3-Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3-Carboxylates and their In-Silico Evaluation Against P-falciparum Lactate Dehydrogenase

机译：基于2-氯喹啉的乙基4-（3-羟基苯基）-2,7,7-三甲基-5-氧-1,4,5,6,7,8-六氢喹啉-3-羧酸的区域选择性合成及其硅内对恶性疟原虫乳酸脱氢酶的评价

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of K2CO3 as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate dehydrogenase.

机译：各种取代的2，4-二氯喹啉与4-（3-羟苯基）-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯的反应为在温和有效的碱K2CO3存在下，在受控温度下进行，得到了具有高区域选择性的新型2-氯喹啉基聚氢喹啉。使用IR，NMR，质谱数据对所有合成的化合物进行表征，然后针对恶性疟原虫乳酸脱氢酶进行计算机模拟分析。

著录项

来源
《Medicinal chemistry》 |2015年第8期|共9页
作者
Rajesh Kancherla; Lavanya Pandian; Iniyavan Pethaperumal; Sarveswari Sundaramoorthy; Ramaiah Sudha; Anbarasu Anand; Vijayakumar Vijayaparthasarathi;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
Polyhydroquinoline; 2; 4-Dichloroquinolines; regioselectivity; in-silico analysis; P. falciparum lactate dehydrogenase;

机译：聚氢喹啉;2;4-二氯喹啉;区域选择性;计算机模拟分析;P。恶性乳酸乳酸脱氢酶;

相似文献

外文文献
中文文献
专利

1. Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3-Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3-Carboxylates and their In-Silico Evaluation Against P-falciparum Lactate Dehydrogenase [J] . Rajesh Kancherla, Lavanya Pandian, Iniyavan Pethaperumal, Medicinal chemistry . 2015,第8期

机译：基于2-氯喹啉的乙基4-（3-羟基苯基）-2,7,7-三甲基-5-氧-1,4,5,6,7,8-六氢喹啉-3-羧酸的区域选择性合成及其硅内对恶性疟原虫乳酸脱氢酶的评价
2. Synthesis and Crystal Structure of Ethyl 2,7,7-Trimethyl-4-(4'-methylphenyl)- 5-oxo-1,4,5,6,7,8-hexahy droquinoline-3- carboxylate in Aqueous Medium [J] . SHI Da-Qing, MOU Jie, ZHUANG Qi-Ya, Chinese Journal of Structural Chemistry . 2005,第6期

机译：水溶液中2,7,7-三甲基-4-（4'-甲基苯基）-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯的合成及晶体结构
3. Synthesis and spectroscopic characterization and DFT study of benzyl 4-([1,1 '-biphenyl]-4-yl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate [J] . Yildirim Sema Ozturk, Buyukmumcu Zeki, Butcher Ray J., Journal of Molecular Structure . 2020,第期

机译：苄基4 - （[1,1'-Biphenyl] -4-×4-1-5-氧代-1,4,5,6,7,8- 六碳喹啉-3-羧酸盐
4. In Vitro Study of Ethyl-4-(3,4.5-trimethoxyphenyl)-2,7,7- trimethyl-5-oxo1,4,5,6,7,8-hexahydroquinoline-3-carboxylate and Bovine Serum Albumin Using Multi-Spectroscopic Techniques and Molecular Docking [C] . Sunil D. Kumbhar, Anil H. Gore, Prafulla B. Choudhari International Conference on Advances in Materials Science . 2019

机译：乙基-4-（3,4.5-三甲氧基苯基）-2,7,7-三甲基-5-氧代1,4,5,6,7,8-六羟基喹啉-3-羧酸盐和牛血清白蛋白使用多重的体外研究光谱技术和分子对接
5. Synthesis and Evaluation of Anti-acetylcholinesterase Activity of 2-(2-(4-(2-Oxo-2-phenylethyl)piperazin-1-yl) ethyl)Isoindoline-13-dione Derivatives with Potential Anti-Alzheimer Effects [O] . Alireza Aliabadi, Alireza Foroumadi, Ahmad Mohammadi-Farani, 2013

机译：具有潜在抗阿尔茨海默氏效应的2-（2-（2-（4-（2-Oxo-2-苯基乙基）哌嗪-1-基）乙基）异吲哚啉-13-二酮衍生物的合成和抗乙酰胆碱酯酶活性的评估
6. Ethyl 4-(3-hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate [O] . P. Mookiah, K. Rajesh, T. Narasimhamurthy, 2009

机译：4-（3-羟基苯基）-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯

Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3-Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3-Carboxylates and their In-Silico Evaluation Against P-falciparum Lactate Dehydrogenase

摘要

著录项

相似文献

相关主题

期刊订阅