• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medicinal chemistry >Seeds of Peganum Harmala L. Chemical Analysis, Antimalarial and Antioxidant Activities, and Cytotoxicity Against Human Breast Cancer Cells
【24h】

Seeds of Peganum Harmala L. Chemical Analysis, Antimalarial and Antioxidant Activities, and Cytotoxicity Against Human Breast Cancer Cells

机译：Peganum Harmala L的种子。化学分析，抗疟和抗氧化活性以及对人乳腺癌细胞的细胞毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study evaluated the levels of total phenolics, flavonoids, tannins and anthocyanins from Peganum harmala L. seeds and determined their antioxidant, antiplasmodial and anticancer potentials. Antioxidant activity was determined by DPPH and ABTS assays. Extracts of P. harmala seeds from Oudref and Djerba (two places in Tunisia) were obtained by successive extraction solvents: petroleum ether, chloroform, ethyl acetate, ethanol and water. Their composition was evaluated for phenolics (gallic acid equivalent 2.48 to 72.52 g/kg), tannins (catechin equivalent 0 to 25.27 g/kg), anthocyanins (cyanidin equivalent 0 to 20.56 mg/kg) and flavonoids (quercetin equivalent 0 to 3.12 g/kg). Ethanolic extract exerted the highest activities against a chloroquine-resistant strain of Plasmodium falciparum (IC50=23 mg/L), against human breast cancer cells MCF7 (IC50=32 mg/L) and against free radical (IC50=19.09 +/- 3.07 mg/L). Correlations were studied between each chemical family and the three activities. Total phenolics content exhibited the highest correlation with antiplasmodial activity (R-2=0.92) and with anticancer activity (R-2=0.86), respectively.
机译：本研究评估了来自Peganum harmala L.种子的总酚，类黄酮，单宁和花色苷的水平，并确定了它们的抗氧化剂，抗疟原虫和抗癌潜力。抗氧化剂活性通过DPPH和ABTS测定法确定。通过连续提取溶剂：石油醚，氯仿，乙酸乙酯，乙醇和水，从Oudref和Djerba（突尼斯的两个地方）提取了harmala种子的提取物。对它们的组成进行了酚类（加仑酸当量2.48至72.52 g / kg），单宁酸（儿茶素当量0至25.27 g / kg），花色苷（花青素当量0至20.56 mg / kg）和类黄酮（槲皮素当量0至3.12 g）进行了评估。 /公斤）。乙醇提取物对恶性疟原虫的耐氯喹菌株（IC50 = 23 mg / L），对人乳腺癌细胞MCF7（IC50 = 32 mg / L）和对自由基（IC50 = 19.09 +/- 3.07）的活性最高毫克/升）。研究了每个化学家族与这三种活性之间的相关性。总酚含量分别与抗疟原虫活性（R-2 = 0.92）和抗癌活性（R-2 = 0.86）具有最高的相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号