Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazInylcarbonyl moiety

Wei Xuan; Wen Ding; Hong-xiang Hui; San-qi Zhang

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Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazInylcarbonyl moiety

机译：具有4-甲基哌嗪基乙烯基羰基的二芳基脲衍生物的合成和细胞毒活性

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Eleven diarylurea derivatives (1a-1k) bearing N-methylpiperazinyl moiety were synthesized by the reaction of isocyanate with arylamine. The structures of la-1k were characterized by ~1H-NMR and MS. The cytotoxic activities of la-1k were evaluated via MTT method against human lung adenocarcinoma epithelial cell line A549 and human prostate carcinoma cell line PC3. Compounds 1d and 1k displayed potent cytotoxic activity. The results suggested that the activities are considerably related to the substituent group at another phenyl ring.

机译：通过异氰酸酯与芳基胺的反应合成了11个带有N-甲基哌嗪基部分的二芳基脲衍生物（1a-1k）。 la-1k的结构通过〜1H-NMR和MS表征。通过MTT方法评估了la-1k对人肺腺癌上皮细胞系A549和人前列腺癌细胞系PC3的细胞毒活性。化合物1d和1k显示出强大的细胞毒活性。结果表明，活性与另一个苯环上的取代基有很大关系。

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《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 |2013年第8期|共6页
作者
Wei Xuan; Wen Ding; Hong-xiang Hui; San-qi Zhang;
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正文语种 eng
中图分类药学;
关键词
Diaryl urea; Synthesis; Cytotoxic activity;

机译：二芳基脲;合成;细胞毒性;

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1. Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazInylcarbonyl moiety [J] . Wei Xuan, Wen Ding, Hong-xiang Hui, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2013,第8期

机译：具有4-甲基哌嗪基乙烯基羰基的二芳基脲衍生物的合成和细胞毒活性
2. Design, synthesis and anticancer activities of diaryl urea derivatives bearing N-acylhydrazone moiety [J] . Zhang B., Zhao Y., Zhai X., Chemical and Pharmaceutical Bulletin . 2012,第8期

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Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazInylcarbonyl moiety

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