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首页> 外文期刊>Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents >Antibacterial and antifungal oxovanadinm(IV) complexes of triazole-derived Schiff bases
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Antibacterial and antifungal oxovanadinm(IV) complexes of triazole-derived Schiff bases

机译：三唑衍生的席夫碱的抗菌和抗真菌的氧杂钒胺（IV）配合物

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摘要

A newly synthesised series of antibacterial and antifungal triazole-derived Schiff base ligands (L1)-(L5) has been prepared by the condensation reaction of 3,5-diamino-l,2,4-triazole with methyl-, chloro- and nitro-substituted thiophene-2-carboxaldehydes in (1:2) molar ratio. The most probable structures of the synthesised Schiff base ligands were established on the basis of their physical, spectral (IR, ~1H and 13C NMR and mass spectrometry) and analytical (CHN analysis) data. These Schiff bases potentially act as bidentate ligand and were further made to react with the vanadyl(IV) sulphate (VOSO4-5H2O) in (1:2) (metahligand) molar ratio to prepare their oxovanadium(IV) complexes (l)-(5). All oxo-vanadium(IV) complexes showed a square-pyramidal geometry which was established on the basis of their physical, spectral and analytical data. The Schiff base ligands and their vanadyl(IV) complexes have been screened for their in vitro antibacterial, antifungal and brine shrimp bioassay. The antimicrobial activity data showed the vanadyl(IV) complexes to be more potent antibacterial and antifungal than the parent Schiff bases against one or more bacterial and fungal species.
机译：通过3,5-二氨基-1,2,4-三唑与甲基，氯和硝基的缩合反应制备了一系列新合成的抗菌和抗真菌三唑衍生的席夫碱配体（L1）-（L5） （1：2）摩尔比的取代的噻吩-2-甲醛。合成的席夫碱配体最可能的结构是根据其物理，光谱（IR，〜1H和13C NMR和质谱）和分析（CHN分析）数据确定的。这些席夫碱可能充当二齿配体，并进一步使其与摩尔比为（1：2）（偏配体）的硫酸氧钒（IV）（VOSO4-5H2O）反应以制备其氧钒（IV）配合物（l）-（ 5）。所有的氧钒钒（IV）络合物均显示出正方形的金字塔形几何形状，该几何形状是根据其物理，光谱和分析数据而建立的。已对席夫碱配体及其钒基（IV）配合物进行了体外抗菌，抗真菌和盐水虾生物测定的筛选。抗菌活性数据表明，与一种或多种细菌和真菌种类的亲本席夫碱相比，钒（Ⅳ）配合物具有更强的抗菌和抗真菌作用。

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