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Analyzing the quality robustness of chemotherapy plans with respect to model uncertainties

机译:针对模型不确定性分析化疗方案的质量稳健性

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Mathematical models of chemotherapy planning problems contain various biomedical parameters, whose values are difficult to quantify and thus subject to some uncertainty. This uncertainty propagates into the therapy plans computed on these models, which poses the question of robustness to the expected therapy quality. This work introduces a combined approach for analyzing the quality robustness of plans in terms of dosing levels with respect to model uncertainties in chemotherapy planning. It uses concepts from multicriteria decision making for studying parameters related to the balancing between the different therapy goals, and concepts from sensitivity analysis for the examination of parameters describing the underlying biomedical processes and their interplay. This approach allows for a profound assessment of a therapy plan, how stable its quality is with respect to parametric changes in the used mathematical model. (C) 2014 Elsevier Inc. All rights reserved.
机译:化疗计划问题的数学模型包含各种生物医学参数,其值难以量化,因此存在一些不确定性。这种不确定性传播到了在这些模型上计算出的治疗计划中,这对预期的治疗质量提出了稳健性的问题。这项工作引入了一种综合方法,可以根据剂量水平与化疗计划中的模型不确定性进行分析,以分析计划的质量稳健性。它使用来自多标准决策的概念来研究与不同治疗目标之间的平衡相关的参数,并使用来自敏感性分析的概念来检查描述基本生物医学过程及其相互作用的参数。这种方法可以对治疗计划进行深入评估,就所用数学模型中的参数变化而言,其质量如何稳定。 (C)2014 Elsevier Inc.保留所有权利。

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