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首页> 外文期刊>Metabolism: Clinical and Experimental >In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome
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In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome

机译：患有和没有代谢综合征的肥胖受试者体内的一氧化氮合成，胰岛素敏感性和不对称二甲基精氨酸

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Metabolic syndrome (MetSyn) is associated with impaired endothelial function. Here the association between nitric oxide (NO) production and insulin sensitivity (Si) in obese subjects with and without MetSyn was evaluated. The relationship between NO production and asymmetric dimethylarginine (ADMA) was also explored. Seven healthy normal-weight subjects (male/female [M/F], 3/4; age, 27.4 ± 10.9 years; body mass index [BMI], 21.9 ± 2.2 kg/m 2), 7 obese subjects without MetSyn (M/F, 1/6; age, 48.0 ± 8.0 years; BMI, 34.5 ± 2.3 kg/m 2), and 7 with MetSyn (M/F, 3/4; age, 48.0 ± 10.7 years; BMI, 33.4 ± 2.9 kg/m 2) were recruited. Body composition and cardiometabolic functions (blood pressure, glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein, ADMA) were measured. A frequent sampling intravenous glucose tolerance test was performed to measure Si. A novel stable isotopic method was used to measure in vivo rates of NO production. The NO production was lower in obese subjects with MetSyn compared with normal-weight subjects and obese subjects without MetSyn. Similarly, Si was significantly lower in obesity, both without and with MetSyn, compared with the control group. A significant direct association was found between NO synthesis and Si (ρ = 0.47, P =.03). Circulating levels of ADMA were significantly higher in the obese group with MetSyn. A nonsignificant negative trend between ADMA and NO synthesis was observed. The association between Si and NO production suggests a close mechanistic link between endothelial function and insulin signaling. The results may be highly informative for the development of controlled longitudinal interventions to improve endothelial and metabolic regulation.
机译：代谢综合征（MetSyn）与内皮功能受损有关。在这里，对有或没有MetSyn的肥胖受试者的一氧化氮（NO）产生与胰岛素敏感性（Si）之间的关联进行了评估。还探讨了NO产生与不对称二甲基精氨酸（ADMA）之间的关系。 7名健康体重正常的受试者（男性/女性[M / F]，3/4;年龄，27.4±10.9岁;体重指数[BMI]，21.9±2.2 kg / m 2），7名没有MetSyn的肥胖受试者（M / F，1/6;年龄，48.0±8.0年; BMI，34.5±2.3 kg / m 2，以及7位具有MetSyn的患者（M / F，3/4;年龄，48.0±10.7岁; BMI，33.4±2.9 kg / m 2）。测量身体成分和心脏代谢功能（血压，葡萄糖，胰岛素，甘油三酸酯，总胆固醇，高密度脂蛋白，ADMA）。进行频繁采样的静脉葡萄糖耐量试验以测量Si。一种新颖的稳定同位素方法用于测量体内NO生成速率。与正常体重的受试者和没有MetSyn的肥胖受试者相比，患有MetSyn的肥胖受试者的NO生成量较低。同样，与对照组相比，无论是否使用MetSyn，Si的肥胖率均显着降低。发现NO合成与Si之间存在显着的直接关联（ρ= 0.47，P = .03）。使用MetSyn的肥胖组的ADMA循环水平明显更高。观察到ADMA与NO合成之间没有显着的负趋势。 Si与NO产生之间的关联表明内皮功能与胰岛素信号传导之间存在密切的机械联系。该结果对于开发可改善内皮和代谢调节的纵向控制干预措施可能具有很高的参考价值。

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