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Insulin sensitivity in Chinese: Inter-relations with obesity and other components of the metabolic syndrome.

机译：中文翻译手机版胰岛素敏感性：与肥胖症和代谢综合征其他成分的相互关系。

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摘要

These studies address the roles of insulin sensitivity and obesity in the metabolic syndrome (MES) in Chinese. No measure of insulin sensitivity suitable for use in cross-sectional studies exists. We modified the short-insulin tolerance test (SITT) and evaluated its safety and efficacy in 11 healthy subjects. Using three intravenous doses of insulin (0.1, 0.05 and 0.01 U·kg-1), plasma glucose concentrations were analysed by standard analyses and by my new analysis. The new analysis was individualised and allowed early termination of the test should hypoglycaemia occur. The 0.1 U·kg-1 dose data analysed by the new analysis gave the most reproducible results.;In young 27 Chinese diabetic patients, the SITT correlated better with variables associated with MES than the intravenous glucose tolerance test and measures derived from fasting insulin and glucose concentrations.;We compared variables from the SITT with known risk factors for MES in healthy 33 Chinese and 31 Caucasian volunteers. The Chinese were significantly less sensitive to insulin than the Caucasians. In addition, the Chinese had significantly higher HbA1c concentrations, although fasting glucose and insulin concentrations did not differ.;The roles of insulin sensitivity and obesity in the clustering of metabolic variables associated with MES were also examined in 145 Chinese subjects. Reduced insulin sensitivity was related dyshpidaemia, hyperglycaemia and central adiposity, independently of age, body mass index and gender, but was not related to hypertension. Visceral and subcutaneous fat had separate metabolic consequences, with only visceral fat affecting diastolic blood pressure, insulin sensitivity and lipid concentrations, while subcutaneous fat was related to increases in non-esterified fatty acids and urate, and decreases in bilirubin concentrations. An exploratory factor analysis of the entire data set suggested that obesity, and not insulin sensitivity, was linking blood pressure, glucose intolerance and dyslipidaemia in these Chinese subjects.;Healthy Chinese may be less sensitive to exogenous insulin than Caucasians and insulin resistance alone may not be responsible for the clustering of metabolic abnormalities in Chinese. Multivariate analysis suggests that obesity links the facets of MES in Chinese, and that those most at risk of developing multiple metabolic derangements are those with insulin resistant obesity.
机译：这些研究探讨了胰岛素敏感性和肥胖在中国代谢综合征（MES）中的作用。没有适合于横断面研究的胰岛素敏感性测量指标。我们修改了短胰岛素耐受性测试（SITT），并评估了其在11位健康受试者中的安全性和有效性。使用三种静脉注射剂量的胰岛素（0.1、0.05和0.01 U·kg-1），通过标准分析和我的新分析来分析血浆葡萄糖浓度。新的分析是个性化的，并允许在发生低血糖时尽早终止测试。通过新分析分析的0.1 U·kg-1剂量数据提供了最可重复的结果。在27位年轻的中国糖尿病患者中，SITT与MES相关变量的相关性比静脉葡萄糖耐量试验和空腹胰岛素，我们在健康的33名中国人和31名白种人志愿者中将SITT变量与已知的MES危险因素进行了比较。中国人对胰岛素的敏感性明显低于白种人。此外，尽管空腹血糖和胰岛素浓度没有差异，但中国人的HbA1c浓度明显较高。在145位中国受试者中，还研究了胰岛素敏感性和肥胖在与MES相关的代谢变量聚类中的作用。胰岛素敏感性降低与血脂异常，高血糖和中央肥胖有关，与年龄，体重指数和性别无关，但与高血压无关。内脏脂肪和皮下脂肪具有单独的代谢后果，只有内脏脂肪会影响舒张压，胰岛素敏感性和脂质浓度，而皮下脂肪则与非酯化脂肪酸和尿酸盐的增加以及胆红素浓度的降低有关。对整个数据集的探索性因素分析表明，肥胖而非胰岛素敏感性与这些中国受试者的血压，葡萄糖耐量和血脂异常有关。健康的中国人对外源胰岛素的敏感性可能不及白种人，仅凭胰岛素抵抗负责中文代谢异常的聚类。多变量分析表明，肥胖与中国人MES的各个方面息息相关，而那些患有多种代谢紊乱风险最大的人群是那些胰岛素抵抗性肥胖者。

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  • 作者

    Anderson, Patricia Jane.;

  • 作者单位

    The Chinese University of Hong Kong (Hong Kong).;

  • 授予单位 The Chinese University of Hong Kong (Hong Kong).;
  • 学科 Health Sciences Medicine and Surgery.;Health Sciences Public Health.;Sociology Ethnic and Racial Studies.
  • 学位 Ph.D.
  • 年度 1999
  • 页码 337 p.
  • 总页数 337
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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