Mitogen requirement for cell cycle progression in the absence of pocket protein activity.

Foijer F; Wolthuis RM; Doodeman V; Medema RH; te Riele H

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Mitogen requirement for cell cycle progression in the absence of pocket protein activity.

机译：在缺乏口袋蛋白活性的情况下，细胞周期进程需要的丝裂原。

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Primary mouse embryonic fibroblasts lacking expression of all three retinoblastoma protein family members (TKO MEFs) have lost the G1 restriction point. However, in the absence of mitogens these cells become highly sensitive to apoptosis. Here, we show that TKO MEFs that survive serum depletion pass G1 but completely arrest in G2. p21CIP1 and p27KIP1 inhibit Cyclin A-Cdk2 activity and sequester Cyclin B1-Cdk1 in inactive complexes in the nucleus. This response is alleviated by mitogen restimulation or inactivation of p53. Thus, our results disclose a cell cycle arrest mechanism in G2 that restricts the proliferative capacity of mitogen-deprived cells that have lost the G1 restriction point. The involvement of p53 provides a rationale for the synergism between loss of Rb and p53 in tumorigenesis.

机译：缺少所有三个视网膜母细胞瘤蛋白家族成员（TKO MEF）表达的原代小鼠胚胎成纤维细胞失去了G1限制点。但是，在没有促分裂原的情况下，这些细胞对凋亡高度敏感。在这里，我们显示在血清消耗中幸存的TKO MEF通过G1但完全滞留在G2中。 p21CIP1和p27KIP1抑制细胞核中非活性复合物中的细胞周期蛋白A-Cdk2活性并隔离细胞周期蛋白B1-Cdk1。有丝分裂原的再刺激或p53的失活减轻了这种反应。因此，我们的结果揭示了G2中的细胞周期停滞机制，该机制限制了失去了G1限制点的有丝分裂原剥夺的细胞的增殖能力。 p53的参与为肿瘤发生中Rb的丢失和p53之间的协同作用提供了理论基础。

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《Cancer Cell》 |2005年第6期|共12页
作者
Foijer F; Wolthuis RM; Doodeman V; Medema RH; te Riele H;
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正文语种 eng
中图分类肿瘤学;
关键词
Cell Cycle; Mitogens; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; 细胞周期; 有丝分裂原; 视网膜母细胞瘤蛋白质;

机译：Cell Cycle;Mitogens;Retinoblastoma Protein;Retinoblastoma-Like Protein p107;细胞周期;有丝分裂原;视网膜母细胞瘤蛋白质;

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专利

1. Mitogen requirement for cell cycle progression in the absence of pocket protein activity. [J] . Foijer F, Wolthuis RM, Doodeman V, Cancer Cell . 2005,第6期

机译：在缺乏口袋蛋白活性的情况下，细胞周期进程需要的丝裂原。
2. Delayed Cell Cycle Progression in Selenoprotein W-depleted Cells Is Regulated by a Mitogen-activated Protein Kinase Kinase 4-p38/c-Jun NH2-terminal Kinase-p53 Pathway [J] . Wayne Chris Hawkes, Zeynep Alkan The Journal of biological chemistry . 2012,第33期

机译：硒蛋白W-耗尽细胞中的延迟细胞周期进展由丝裂原激活的蛋白激酶激酶4-P38 / C-Jun NH2-末端激酶-P53途径调节
3. Garlic components inhibit angiotensin II-induced cell-cycle progression and migration: involvement of cell-cycle inhibitor p27Kip1 and mitogen-activated protein kinase. [J] . Castro C., Gil Lorenzo A., Gonzalez A., Molecular Nutrition and Food Research . 2010,第6期

机译：大蒜成分抑制血管紧张素II诱导的细胞周期进程和迁移：细胞周期抑制剂p27Kip1和有丝分裂原激活的蛋白激酶的参与。
4. Inhibition of cell cycle progression in cells expressing HCV proteins [C] . A.R. Ciccaglione, E. Tritarelli, C. Marcantonio, European Congress of Virology . 2004

机译：表达HCV蛋白细胞细胞周期进展的抑制作用
5. N-terminally regulated pRb, differential regulation of E2F-responsive genes by pocket protein family members and CDKs, and cell cycle progression [D] . Gorges, Laura L. 2008

机译：N末端调节的pRb，口袋蛋白家族成员和CDK对E2F应答基因的差异调节以及细胞周期进程
6. Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity. [O] . H Perlman, M Sata, A Le Roux, 1998

机译：Gax同源蛋白引起的Bax介导的细胞死亡需要激活促分裂原但与细胞周期活性无关。
7. Mitogen requirement for cell cycle progression in the absence of pocket protein activity [O] . Foijer Floris, Wolthuis Rob M.F., Doodeman Valerie, 2006

机译：在缺乏口袋蛋白活性的情况下细胞周期进程中的丝裂素需求

Mitogen requirement for cell cycle progression in the absence of pocket protein activity.

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