Survival of cancer cells is maintained by EGFR independent of its kinase activity.

Weihua Z; Tsan R; Huang WC; Wu Q; Chiu CH; Fidler IJ; Hung MC

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Survival of cancer cells is maintained by EGFR independent of its kinase activity.

机译：EGFR维持癌细胞的生存而与其激酶活性无关。

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Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

机译：在许多上皮起源的肿瘤中，表皮生长因子受体（EGFR）（一种与细胞增殖和存活相关的酪氨酸激酶）的表达过度活跃。 EGFR激酶活性的阻断已用于癌症治疗。然而，就其本身而言，它似乎未达到最大的治疗功效。我们在这里报告，在人类癌细胞中，激酶依赖性EGFR的功能是通过钠/葡萄糖共转运蛋白1（SGLT1）的相互作用和稳定来维持细胞内葡萄糖水平，从而防止自噬细胞死亡。

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来源
《Cancer Cell》 |2008年第5期|共9页
作者
Weihua Z; Tsan R; Huang WC; Wu Q; Chiu CH; Fidler IJ; Hung MC;
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正文语种 eng
中图分类肿瘤学;
关键词
Autophagy; Cell Death; Cell Division; Cell Survival; Glucose; Homeostasis; 细胞死亡; 细胞分裂; 细胞存活; 葡萄糖; 体内稳态; 动力学; 肿瘤转移; 肿瘤;

机译：Autophagy;Cell Death;Cell Division;Cell Survival;Glucose;Homeostasis;细胞死亡;细胞分裂;细胞存活;葡萄糖;体内稳态;动力学;肿瘤转移;肿瘤;

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1. Survival of cancer cells is maintained by EGFR independent of its kinase activity. [J] . Weihua Z, Tsan R, Huang WC, Cancer Cell . 2008,第5期

机译：EGFR维持癌细胞的生存而与其激酶活性无关。
2. Clinical Impact of Post-Progression Survival on Overall Survival in Elderly Patients with Non-Small-Cell Lung Cancer Harboring Sensitive EGFR Mutations Treated with First-Line EGFR Tyrosine Kinase Inhibitors [J] . Imai Hisao, Yamada Yutaka, Sugiyama Tomohide, Chemotherapy: International Journal of Experimental and Clinical Chemotherapy . 2018,第3期

机译：患有一线EGFR酪氨酸激酶抑制剂治疗的患有敏感EGFR突变的老年非小细胞肺癌患者整体生存的临床影响
3. Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells. [J] . Sloss CM, Wang F, Liu R, Clinical cancer research: an official journal of the American Association for Cancer Research . 2008,第16期

机译：蛋白酶体抑制激活胰腺癌细胞中的表皮生长因子受体（EGFR）和不依赖EGFR的有丝分裂激酶信号通路。
4. Association between tumor heterogeneity and progression-free survival in non-small cell lung cancer patients with EGFR mutations undergoing tyrosine kinase inhibitors therapy [C] . Jiangdian Song, Di Dong, Yanqi Huang, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：接受酪氨酸激酶抑制剂治疗的EGFR突变非小细胞肺癌患者肿瘤异质性与无进展生存的关系
5. The role of ligand-independent activation of EGFR in E-cadherin-mediated squamous cell carcinoma cell survival. [D] . Shen, Xiaodong. 2003

机译：EGFR配体非依赖性激活在E-钙黏着蛋白介导的鳞状细胞癌细胞存活中的作用。
6. Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity [O] . Zhang Weihua, Rachel Tsan, Wei-Chien Huang, -1

机译：EGFR维持癌细胞的生存而与它的激酶活性无关
7. Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity [O] . Weihua Zhang, Tsan Rachel, Huang Wei-Chien, 2008

机译：EGFR维持癌细胞的生存而与其激酶活性无关
8. Targeting the Kinase-Independent Pro-survival Function of EGFR in Prostate Cancer. [R] . Zhang, W. 2013

机译：靶向EGFR在前列腺癌中的激酶非依赖性促存活功能。

Survival of cancer cells is maintained by EGFR independent of its kinase activity.

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