...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer Cell >Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells
【24h】

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

机译：工程共刺激的结构设计决定了肿瘤排斥动力学和CAR T细胞的持久性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The costimulatory properties of second-generation chimeric antigen receptors (CARs) determine the overall potency of adoptively transferred T cells. Using an in vivo "stress test'' to challenge CD19-targeted T cells, we studied the functionality and persistence imparted by seven different CAR structures providing CD28 and/or 4-1BB costimulation. One configuration, which uses two signaling domains (CD28 and CD3 zeta) and the 4-1BB ligand, provided the highest therapeutic efficacy, showing balanced tumoricidal function and increased T cell persistence accompanied by an elevated CD8/CD4 ratio and decreased exhaustion. Remarkably, induction of the IRF7/IFN beta pathway was required for optimal anti-tumor activity. Thus, 1928z-41BBL T cells possess strikingly potent intrinsic and immunomodulatory qualities.
机译：T细胞工程学是快速生成抗肿瘤T细胞的有力手段。第二代嵌合抗原受体（CARs）的共刺激特性决定了过继转移T细胞的整体效能。我们使用体内“压力测试”挑战以CD19为目标的T细胞，我们研究了提供CD28和/或4-1BB共刺激的7种不同CAR结构所赋予的功能和持久性。一种配置使用两个信号域（CD28和CD3 zeta）和4-1BB配体提供最高的治疗效果，显示出平衡的杀肿瘤功能和T细胞持久性，并伴有CD8 / CD4比值升高和疲惫状态降低，值得注意的是，IRF7 / IFNβ途径需要诱导因此，1928z-41BBL T细胞具有强大的内在和免疫调节特性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号