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首页> 外文期刊>Microbial Pathogenesis >Acid aspiration induces bacterial pneumonia by enhanced bacterial adherence in mice
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Acid aspiration induces bacterial pneumonia by enhanced bacterial adherence in mice

机译：酸吸入通过增强小鼠的细菌粘附力诱导细菌性肺炎

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The issue of whether acid aspiration facilitates bacterial pneumonia caused by Pseudomonas aeruginosa by enhanced bacterial adherence was examined in mice. Survival or the number of bacteria in lung tissues was evaluated after an intratracheal challenge of hydrochloric acid (HCl), a sublethal dose of P. aeruginosa, or both in mice. Bacterial adherence to the tracheal epithelium after acid aspiration was also examined by scanning electron microscopy. A simultaneous intratracheal challenge of 50 mul of 10(-1) N HCl, but not 10(-2) to 10(-4) N HCl, combined with a sublethal dose of P. aeruginosa significantly increased the number of bacteria in the lung tissues and decreased survival, while all mice that received either HCl or P. aeruginosa survived. Significantly higher numbers of adherent bacteria on the tracheal epithelium were found in mice that received 10(-1) N HCl, compared with mice that received HCl (10(-2) to 10(-4) N) or saline. These data indicate that acid aspiration induced airway epithelial injury and enhanced P. aeruginosa adherence to the epithelium, and led to the subsequent development of bacterial pneumonia in mice. Enhanced bacterial adherence on the acid-injured epithelium may explain fatal bacterial pneumonias in patients with respiratory aspiration of gastric contents.
机译：在小鼠中检查了酸吸入是否通过增强细菌粘附来促进由铜绿假单胞菌引起的细菌性肺炎的问题。在气管内攻击盐酸（HCl），亚致死剂量的铜绿假单胞菌或在小鼠中进行气管内攻击后，评估了肺组织的存活率或细菌数。酸抽吸后细菌对气管上皮的粘附也通过扫描电子显微镜检查。气管内同时挑战50 mul的10（-1）N HCl，但不是10（-2）至10（-4）N HCl，再加上亚致死剂量的铜绿假单胞菌，显着增加了肺中细菌的数量组织和存活率降低，而所有接受HCl或铜绿假单胞菌的小鼠均存活。与接受HCl（10（-2）至10（-4）N）或生理盐水的小鼠相比，接受10（-1）N HCl的小鼠气管上皮上粘附细菌的数量明显增多。这些数据表明酸抽吸引起气道上皮损伤并增强铜绿假单胞菌对上皮的粘附，并导致小鼠细菌性肺炎的随后发展。细菌粘附在酸损伤的上皮上可能解释了胃内容物呼吸吸入患者的致命性细菌性肺炎。

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