Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition

Stewart C. Allison; Byers Lauren Averett

首页> 外文期刊>Cancer Cell >Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition

【24h】

Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition

机译：改变小细胞肺癌的进程：通过抑制LSD1靶向癌干细胞

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In this issue of Cancer Cell, Mohammad et al. describe LSD1, a histone demethylase, as a therapeutic target in SCLC with a unique epigenetic signature to predict drug sensitivity. Inhibition of LSD1 reduces cell proliferation and stem cell maintenance while promoting cell differentiation and reducing tumor growth in preclinical models.

机译：在本期《癌细胞》中，Mohammad等人。描述了组蛋白脱甲基酶LSD1作为SCLC中的治疗靶标，具有独特的表观遗传学特征，可预测药物敏感性。在临床前模型中，抑制LSD1可减少细胞增殖和干细胞维持，同时促进细胞分化并减少肿瘤生长。

著录项

来源
《Cancer Cell》 |2015年第1期|共3页
作者
Stewart C. Allison; Byers Lauren Averett;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition [J] . Stewart C. Allison, Byers Lauren Averett Cancer Cell . 2015,第1期

机译：改变小细胞肺癌的进程：通过抑制LSD1靶向癌干细胞
2. Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition [J] . Augert Arnaud, Eastwood Emily, Ibrahim Ali H., Science Signaling . 2019,第567期

机译：通过LSD1抑制靶向小细胞肺癌中的凹口激活
3. Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer [J] . Diego Serrano, Anne-Marie Bleau, Ignacio Fernandez-Garcia, Molecular Cancer . 2011,第1期

机译：抑制端粒酶活性优先靶向肺癌中醛脱氢酶阳性的癌症干细胞
4. Encapsulation of a potential anticancer drug within multifunctional poly(amidoamine) dendrimers for targeted inhibition of cancer cells [C] . Yin Wang, Rui Guo, Xueyan Cao, 2010 International conference of international conference on combating land degradation in agricultral areas. . 2010

机译：潜在的抗癌药物在多功能聚（酰胺基胺）树状聚合物中的封装，可靶向抑制癌细胞
5. Design and Evaluation of Peptidomimetics and Peptidomimetics Drug Conjugates Targeting HER2 Overexpressing Cells in Breast and Lung Cancers [D] . Pallerla, Sandeep. 2017

机译：拟肽和拟肽药物结合物靶向乳腺癌和肺癌中HER2过表达细胞的设计和评估
6. Altering the Course of Small Cell Lung Cancer: Targeting Cancer StemCells via LSD1 Inhibition [O] . C. Allison Stewart, Lauren Averett Byers -1

机译：改变小细胞肺癌的进程：针对癌症干。通过LSD1抑制的细胞
7. Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition [O] . Stewart C. Allison, Byers Lauren Averett 2015

机译：改变小细胞肺癌的进程：通过抑制LSD1靶向癌干细胞

Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition

摘要

著录项

相似文献

相关主题

期刊订阅