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首页> 外文期刊>Medecine et maladies infectieuses >Antimicrobial susceptibility and genotypic distribution of Neisseria gonorrhoeae: A 2-year study in Tunisia
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Antimicrobial susceptibility and genotypic distribution of Neisseria gonorrhoeae: A 2-year study in Tunisia

机译：淋病奈瑟菌的抗菌药敏性和基因型分布：在突尼斯的一项为期两年的研究

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摘要

Neisseria gonorrhoeae is a major etiological agent of sexually transmitted infections (STI) and may cause severe urogenital complications. Some authors have recently reported a progressive increase in the incidence of gonorrhoeae in many countries. This may indicate a return to high-risk sexual behavior, contributing to the increase of STI, and highlights the need for routine surveillance, prevention, and control measures. Genotyping by pulsed fields gel electrophoresis (PFGE), which is considered as an epidemiological reference marker for several bacterial species, could be used forto N. gonorrhoeae. All the isolates were collected in our laboratory over 2 years (2008-2009), in our region that has a high touristic activity. Antimicrobial susceptibility patterns were determined according to the recommendations of the French society of microbiology. MICs were determined by E-test. The molecular typing was performed by PFGE (CHEF) after macro restriction by Spel. The PFGE patterns were analyzed according to the Tenover criteria. Forty-five isolates were isolated from: vaginal samples (n = 28), urethral samples (n=15), sperm (n=1), and neonatal conjunctival swab (n = 1). Twenty-two isolates were resistant to penicillin, 15 (33.33%) isolates were penicillinase producing N. gonorrhoeae (PPNG), and seven (15.5%) expressed a chromosomalry mediated resistance (CMRNG). Five (11.11%) isolates expressed a plasmid-mediated resistance to tetracycline (TRNG) with a MIC greater than 16 mg/l; two of these carried the combination of both resistance phenotypes (TRNG-PPNG). Fifteen (33.33%) isolates were resistant to ciprofloxacin and four to azithromycin. No antibiotic resistance to spectinomycin and ceftriaxone was observed. Furthermore, three isolates showed reduced susceptibility to ceftriaxone, and only one isolate was resistant to rifampicin. Two out of the four azithromycin resistant isolates were resistant to ciprofloxacin, and the two others were also PPNG.
机译：淋病奈瑟氏球菌是性传播感染（STI）的主要病因，可能会导致严重的泌尿生殖系统并发症。一些作者最近报告说，在许多国家，淋病的发病率逐渐增加。这可能表明已经恢复了高风险的性行为，导致性传播感染的增加，并突出了对常规监测，预防和控制措施的需求。通过脉冲场凝胶电泳（PFGE）进行基因分型，被认为是淋病奈瑟菌的流行病学参考标记。在我们活动频繁的地区，我们的实验室历时2年（2008-2009年）收集了所有分离株。根据法国微生物学会的建议确定了抗菌药的敏感性模式。 MIC通过E检验确定。在通过Spel进行宏观限制之后，通过PFGE（CHEF）进行分子分型。根据Tenover标准对PFGE模式进行了分析。从以下样本中分离出45种分离物：阴道样本（n = 28），尿道样本（n = 15），精子（n = 1）和新生儿结膜拭子（n = 1）。 22株对青霉素有抗药性，其中15株（33.33％）是产生青霉素酶的淋病奈瑟菌（PPNG），其中7株（15.5％）表现出染色体介导的抗药性（CMRNG）。五个（11.11％）分离株表达的质粒介导的四环素（TRNG）耐药性，MIC大于16 mg / l。其中两个携带了两种抗性表型（TRNG-PPNG）的组合。十五株（33.33％）分离株对环丙沙星耐药，四株对阿奇霉素耐药。没有观察到对壮观霉素和头孢曲松的抗生素抗性。此外，三种分离株对头孢曲松的敏感性降低，只有一种分离株对利福平有抗药性。耐阿奇霉素的四个分离株中有两个对环丙沙星耐药，另外两个也是PPNG。

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