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首页> 外文期刊>International journal of urology: official journal of the Japanese Urological Association >Is interval from an initial biopsy a significant predictor of prostate cancer at repeat biopsies?
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Is interval from an initial biopsy a significant predictor of prostate cancer at repeat biopsies?

机译：初次活检的间隔是否是重复活检时前列腺癌的重要预测指标？

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BACKGROUND: Currently, there are no clear criteria for indicating repeat biopsies in patients with negative results at an initial biopsy of the prostate. The aim of the present study is to determine the clinical and pathological parameters which predict prostate cancer at repeat biopsies with special attention to the interval between biopsies in addition to prostate specific antigen (PSA) and its derivatives. METHODS: We reviewed 100 patients who underwent an initial biopsy that proved negative for prostate cancer and required repeat biopsies between November 1996 and November 2003. Clinical parameters such as age, PSA and its derivatives, interval between biopsies, number of cores taken and initial biopsy histology were analyzed. RESULTS: In total, 31 patients (31.0%) were found to have prostate cancer, 18 (25.7%) of 70 patients by the second biopsy and 13 (46.4%) of 28 patients by the third biopsy. Two patients underwent the fourth biopsy, which revealed no prostate cancer. The patients with a positive biopsy had a significantly longer interval between the biopsies than the patients with a negative biopsy (P=0.0036). Furthermore, in both univariate and multivariate logistic regression analysis, only the interval between the biopsies proved to be an independent predictor of positive results at repeat biopsies (P=0.0094 and 0.0019). CONCLUSIONS: Only the biopsy interval was a significant predictor of prostate cancer at repeat biopsies in both univariate and multivariate analysis.
机译：背景：目前，尚无明确标准可指示对患者进行前列腺穿刺活检时阴性的重复活检。本研究的目的是确定在重复活检时预测前列腺癌的临床和病理学参数，除前列腺特异抗原（PSA）及其衍生物外，还要特别注意活检之间的间隔。方法：我们审查了1996年11月至2003年11月间100例经初次活检证实为前列腺癌阴性并需要重复活检的患者。临床参数，例如年龄，PSA及其衍生物，两次活检之间的间隔，取芯次数和初次活检组织学分析。结果：总共31例（31.0％）被发现患有前列腺癌，第二次活检发现70例患者中的18例（25.7％），第三次活检发现28例患者中13例（46.4％）。两名患者进行了第四次活检，没有发现前列腺癌。活检阳性的患者比活检阴性的患者活检间隔显着更长（P = 0.0036）。此外，在单变量和多元逻辑回归分析中，只有活检之间的间隔被证明是重复活检中阳性结果的独立预测因子（P = 0.0094和0.0019）。结论：在单因素和多因素分析中，重复活检时只有活检间隔是前列腺癌的重要预测指标。

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