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首页> 外文期刊>Cancer letters >Numerical defect of circulating dendritic cell subsets and defective dendritic cell generation from monocytes of patients with advanced melanoma
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Numerical defect of circulating dendritic cell subsets and defective dendritic cell generation from monocytes of patients with advanced melanoma

机译：晚期黑色素瘤患者循环树突状细胞亚群的数值缺陷和单核细胞生成树突状细胞的缺陷

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摘要

The behaviour of circulating dendritic cells (DCs) and DC generation from monocytes in melanoma patients during the progression of disease have not been described.We report a significant decrease in the absolute number of total DCs, which mainly affects plasmacytoid DCs in stage IV. Additionally, monocyte-DC generation is less efficient in advanced stages, resulting in DCs that exhibit increased phagocytic capacity, potentially indicating a less mature state. These findings elucidate aspects of basic tumour-mediated immunosuppression, which may have implications for immunotherapeutic approaches, suggesting that the selection of patients for immunotherapy should also be made on the basis of their immune status.
机译：黑色素瘤患者病情发展过程中循环树突状细胞（DC）的行为和单核细胞产生DC的情况尚未描述。我们报道总DC的绝对数量显着减少，这主要影响IV期的浆细胞样DC。另外，单核细胞-DC的产生在晚期阶段效率较低，导致DC的吞噬能力增强，可能表明其成熟状态较差。这些发现阐明了基本肿瘤介导的免疫抑制的各个方面，这可能对免疫治疗方法有影响，表明选择免疫治疗的患者也应基于他们的免疫状态。

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