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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Plasmacytoid dendritic cells represent a major dendritic cell subset in sentinel lymph nodes of melanoma patients and accumulate in metastatic nodes.
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Plasmacytoid dendritic cells represent a major dendritic cell subset in sentinel lymph nodes of melanoma patients and accumulate in metastatic nodes.

机译：浆细胞样树突状细胞代表黑素瘤患者前哨淋巴结中的主要树突状细胞亚群，并在转移性结节中积聚。

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摘要

Plasmacytoid dendritic cells (pDC) represent the main source of interferon-alpha, a cytokine with antitumor activity. However, in vitro studies point to pDC as a key subset for induction of tolerance. Herein, we investigated pDC in sentinel lymph nodes (SLN) of melanoma patients. We report that pDC were constantly found in SLN and represented, with Langerhans cells, the most frequent dendritic cell subset. Their frequency in positive (with metastasis) SLN was significantly higher than in negative (without metastasis) SLN. PDC were observed in the T cell-rich areas of lymph nodes, particularly around high endothelial venules and, in metastatic nodes, they accumulated in close vicinity with melanoma nests. Finally, pDC capability to produce interferon-alpha in situ was impaired. Consistently, pDC expressed CD86, but neither CD80 nor CD83, suggesting a not complete activation in melanoma-draining lymph nodes. These results are consistent with the hypothesis of a tolerogenic role played by pDC in tumor immunology.
机译：浆细胞样树突状细胞（pDC）代表干扰素-α（具有抗肿瘤活性的细胞因子）的主要来源。但是，体外研究指出pDC是诱导耐受的关键子集。在这里，我们调查了黑色素瘤患者前哨淋巴结（SLN）中的pDC。我们报告说，pDC经常在SLN中发现，并以Langerhans细胞代表最常见的树突状细胞亚群。阳性（有转移）SLN的频率显着高于阴性（无转移）SLN。在淋巴结的T细胞富集区域，尤其是高内皮小静脉周围，观察到PDC，在转移性淋巴结中，PDC聚集在黑色素瘤巢附近。最后，pDC原位产生干扰素-α的能力受到损害。一致地，pDC表达CD86，但既不表达CD80，也不表达CD83，表明在黑色素瘤引流的淋巴结中激活不完全。这些结果与pDC在肿瘤免疫学中发挥致耐受作用的假设相一致。

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