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Preclinical lymphatic imaging

机译:临床前淋巴成像

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摘要

Noninvasive in vivo imaging of lymphatic vessels and lymphatic nodes is expected to fulfill the purpose of analyzing lymphatic vessels and their function, understanding molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors, and utilizing lymphatic molecular markers as a prognostic or diagnostic indicator. In this review, we provide a comprehensive summary of in vivo imaging modalities for detecting lymphatic vessels, lymphatic drainage, and lymphatic nodes, which include conventional lymphatic imaging techniques such as dyes and radionuclide scintigraphy as well as novel techniques for lymphatic imaging such as optical imaging, computed tomography, magnetic resonance imaging, ultrasound, positron emission tomography using lymphatic biomarkers, photoacoustic imaging, and combinations of multiple modalities. The field of lymphatic imaging is ever evolving, and technological advances, combined with the development of new contrast agents, continue to improve the research of lymphatic vascular system in health and disease states as well as to improve the accuracy of diagnosis in the relevant diseases.
机译:淋巴管和淋巴结的无创体内成像有望实现以下目的:分析淋巴管及其功能,了解淋巴管生成和肿瘤淋巴扩散的分子机制,并利用淋巴管分子标志物作为预后或诊断指标。在这篇综述中,我们提供了用于检测淋巴管,淋巴引流和淋巴结的体内成像方式的综合摘要,包括常规的淋巴成像技术(例如染料和放射性核素闪烁显像)以及用于淋巴成像的新技术(例如光学成像) ,计算机断层扫描,磁共振成像,超声,使用淋巴生物标记的正电子发射断层扫描,光声成像以及多种模式的组合。淋巴成像领域不断发展,技术进步与新型造影剂的发展相结合,继续改善了健康和疾病状态下淋巴血管系统的研究,并提高了相关疾病的诊断准确性。

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