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首页> 外文期刊>Movement disorders >Accelerometric assessment of levodopa-induced dyskinesias in Parkinson's disease.
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Accelerometric assessment of levodopa-induced dyskinesias in Parkinson's disease.

机译：左旋多巴诱发的帕金森氏病运动障碍的加速度计评估。

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Our objective was to develop parameters for objective ambulatory measurements of levodopa-induced dyskinesias (LID) in patients with Parkinson's disease (PD). Twenty-three PD patients with mild to severe LID were submitted to a standardized protocol of 1-minute recordings during rest, talking, stress, and four activities of daily life (ADL). Patients were simultaneously monitored with portable multi-channel accelerometry (four pairs of bi-axial sensors mounted onto the most affected arm, leg, and at the trunk) and recorded by video. LID severity was assessed with a modified Abnormal Involuntary Movement Scale (m-AIMS). The signals were analyzed, and every 1/8-second interval the amplitude was obtained of the dominant frequency within 1-4 Hz and 4-8 Hz frequency bands (Amp1-4 and Amp4-8). For both measures, convergent validity, reproducibility, and responsiveness were determined. In absence of voluntary movements, a significant relation was found between Amp1-4 and Amp4-8 and m-AIMS. Repeated measurements during rest showed a high reproducibility (intraclass correlation coefficient = 0.90 [Amp1-4] and 0.86 [Amp4-8]). The extent to which LID increased with talking and stress correlated significantly (p = 0.02) between the objective and clinical measures (intraclass correlation for differences = 0.67). During ADL, LID occurred in a similar frequency band as voluntary movements and only Amp1-4 and Amp4-8 of the trunk and leg sensor remained highly correlated with m-AIMS. Although objective measures of LID are reliable and responsive, they fail to distinguish LID from voluntary movements. These measures are of value only when obtained during rest (all sensor sites) or during ADL when derived from those body segments that are normally not involved in these ADL tasks (trunk and leg).
机译：我们的目标是为帕金森氏病（PD）患者的左旋多巴诱发的运动障碍（LID）的动态门诊测量制定参数。 23例轻度至重度LID的PD患者在休息，说话，压力和四种日常生活活动（ADL）期间接受了1分钟记录的标准化方案。用便携式多通道加速度计（四对双轴传感器安装在受影响最大的手臂，腿部和躯干上）同时监视患者，并通过视频记录。 LID严重程度通过修订的异常非自愿运动量表（m-AIMS）进行评估。对信号进行分析，并每隔1/8秒间隔获得1-4 Hz和4-8 Hz频带（Amp1-4和Amp4-8）内主频率的幅度。对于这两种方法，都确定了收敛效度，可重复性和响应性。在没有自愿运动的情况下，在Amp1-4和Amp4-8与m-AIMS之间发现了显着的关系。休息期间重复测量显示出高重复性（类内相关系数= 0.90 [Amp1-4]和0.86 [Amp4-8]）。 LID随着说话和压力而增加的程度在客观和临床测量之间显着相关（p = 0.02）（类内相关性差异= 0.67）。在ADL期间，LID发生在与自愿运动相似的频带中，只有躯干和腿部传感器的Amp1-4和Amp4-8与m-AIMS高度相关。尽管LID的客观测量是可靠和响应的，但它们无法将LID与自愿运动区分开。这些措施只有在休息时（所有传感器部位）或在ADL期间获得的价值才有价值，这些措施是从通常不参与这些ADL任务（躯干和腿部）的那些身体部位获得的。

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