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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Sister chromatid exchange frequency is elevated and cell proliferation is delayed in bone marrow cells of starved and marginally malnourished rats
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Sister chromatid exchange frequency is elevated and cell proliferation is delayed in bone marrow cells of starved and marginally malnourished rats

机译：在饥饿和边缘营养不良的大鼠的骨髓细胞中，姐妹染色单体交换频率提高，细胞增殖延迟

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摘要

The frequency of sister chromatid exchanges (SCE) and the cell proliferation kinetic were analyzed in bone marrow (BM) cells of Wistar rats subjected to starvation and marginal malnutrition (MN) after 24h of 5'bromo-depxyuridine (BdUr) implantation. SCE were analyzed in a minimum of 18 consecutive second division metaphases and for cell proliferation, 100 consecutive metaphases were analyzed and classified into the first, second and third or subsequent replication cycles. Rats subjected to starvationand MN exhibited significantly higher mean SCE per lymphocyte in bone marrow than the well nourished rats. Further, they also showed a longer proliferation kinetic in BM cells, These observations indicate that starvation and MN per se resulted in greater SCE and prolongation of the cell cycle in experimental animals. On rehabilitation, the cells with high SCE frequency and prolonged cell cycle in both starved and MN rats were comparable to control groups.
机译：在5'溴脱去氧尿苷（BdUr）植入24小时后，对遭受饥饿和边缘营养不良（MN）的Wistar大鼠骨髓（BM）细胞进行染色单体交换（SCE）频率和细胞增殖动力学分析。在至少18个连续的第二分裂中期对SCE进行了分析，对于细胞增殖，对100个连续的中期进行了分析，并将其分为第一，第二和第三或随后的复制周期。遭受饥饿和MN的大鼠与营养良好的大鼠相比，骨髓中每淋巴细胞的平均SCE显着更高。此外，它们还显示了在BM细胞中更长的增殖动力学。这些观察结果表明，饥饿和MN本身会导致实验动物的SCE值增加和细胞周期延长。康复时，饥饿和MN大鼠的SCE频率高且细胞周期延长的细胞与对照组相当。

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