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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Genotoxic potential of beta-carbolines: a review
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Genotoxic potential of beta-carbolines: a review

机译：β-咔啉的遗传毒性潜力：综述

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摘要

The mutagenic and co-mutagenic properties of hurmarv norharman and of some of their pharmacologically important derivatives are reviewed. These compounds do not behave as true mutagens, but rather interact, directly or indirectly with DNA, leading tovarious consequences. This unusual behaviour is most probably related to the particular structure of the chemical nucleus common to all beta-carbolines which confers to the different derivatives the property to interact with various macromolecules and enzymatic systems. These interactions are compiled and discussed in this review. The alterations, by beta-carbolines, of some important enzymatic systems, e.g. cytochromc P-450, have been clearly demonstrated, yet many discrepancies and contradictions exist so that an interpretation of the results and the definition of some common mechanism appears premature. Since beta-carbolines are widely distributed in tissues and since they may modify and increase genotoxic and toxic consequences of other compounds,these interactions need to be clarified.
机译：综述了hurmarv norharman及其一些药理重要衍生物的诱变和共诱变特性。这些化合物的行为不像真正的诱变剂，而是直接或间接与DNA相互作用，导致各种后果。这种异常行为很可能与所有β-咔啉共有的化学核的特定结构有关，这种结构赋予不同的衍生物与各种大分子和酶系统相互作用的特性。这些相互作用在本综述中进行了汇编和讨论。 β-咔啉对一些重要酶系统的改变，例如已经清楚地证明了细胞色素P-450，但仍存在许多差异和矛盾，因此对结果的解释和某些共同机制的定义似乎为时过早。由于β-咔啉广泛分布在组织中，并且由于它们可能修饰和增加其他化合物的遗传毒性和毒性后果，因此需要澄清这些相互作用。

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