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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Genetic toxicology of four commonly used benzodiazepines: A review
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Genetic toxicology of four commonly used benzodiazepines: A review

机译：四种常用苯二氮卓类的遗传毒理学：一个综述

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摘要

Benzodiazcpines are a group of drugs which have been extensively used for their activities as an anti-anxiety, sedative, muscle relaxant and anti-convulsant. Benzodiazepines at present are the most commonly prescribed drugs. Some of these drugs are terutogenic and also carcinogenic in experimental animals. The wide human exposure to this group of drugs throughout the world is of great concern for human health. In the present review, we have attempted to evaluate and update the mtitagcnic and genotoxic effects of four of the most commonly used benzodiazepines, i.e., chtordiazepoxide (CDZ), diazepam (DZ), nitfozepam (NZ) and oxnzepam (OZ) based on available literature.
机译：苯并二氮pine类是一类已广泛用作抗焦虑，镇静剂，肌肉松弛剂和抗惊厥药的药物。目前，苯二氮卓类药物是最常用的处方药。其中一些药物在实验动物中具有致畸性和致癌性。人类在全世界范围内广泛接触这组药物是人类健康的重大关切。在本综述中，我们尝试根据可用的方法评估和更新四种最常用的苯二氮卓类药物的多态性和遗传毒性作用，即苯二氮卓（CDZ），地西epa（DZ），尼硝西am（NZ）和奥氮西epa（OZ）文学。

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