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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >CYCLOHEXIMIDE AND BUTHIONINE SULFOXIMINE PREVENT INDUCTION OF GENOTOXIC ADAPTATION BY CADMIUM SALT AGAINST METHYL MERCURIC CHLORIDE IN EMBRYONIC SHOOT CELLS OF HORDIUM VULGARE L
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CYCLOHEXIMIDE AND BUTHIONINE SULFOXIMINE PREVENT INDUCTION OF GENOTOXIC ADAPTATION BY CADMIUM SALT AGAINST METHYL MERCURIC CHLORIDE IN EMBRYONIC SHOOT CELLS OF HORDIUM VULGARE L

机译：环己二胺和丁硫氨酸亚砜亚胺可预防镉盐对甲基汞的胚芽细胞的遗传氧化适应

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摘要

Presoaked seeds of barley Hordeum vulgare L. pretreated with cycloheximide (CH), 10(-6) M or bythionine sulfoximine (BSO), 10(-4) M, were exposed to methyl mercuric chloride (MMCl), 10(-4) M, with or whitout prior conditioning with cadmium sulfate (CdSO4), 10(-4) M. Subsequently as the seeds germinated the endpoints measured were mitotic index, cells with mitotic aberrations and micronuclei (MNC) in embryonic shoot cells fixed at 40, 44, 48 and 52 h of recovery. Indicated by the significant reduction (p less than or equal to 0.05) of the yield of cells with aberrations or MNC, the results confirmed that CdSO4-conditioning triggered an adaptive response to MMCl-challenge. Pretreatments of CH and BSO, whereas they potentiated the genotoxicity of MMCl, significantly prevented (p less than or equal to 0.05) the Cd-induced genotoxic adaptation. That underscores a possible involvement of proteins in addition to phytochelatins in the underlaying mechanisms.
机译：将大麦大麦经环己酰亚胺（CH），10（-6）M或甲硫氨酸亚磺酰亚胺（BSO），10（-4）M预处理的预浸种子暴露于甲基汞氯化物（MMCl），10（-4） M，先用硫酸镉（CdSO4）调理，再用10（-4）M调理。随后，随着种子萌发，所测终点为有丝分裂指数，胚芽细胞中有丝分裂和微核（MNC）的细胞固定为40，恢复44、48和52小时。通过畸变或MNC的细胞产量的显着降低（p小于或等于0.05）表明，结果证实CdSO4调节触发了对MMC1挑战的适应性反应。 CH和BSO的预处理虽然增强了MMCl的遗传毒性，但可以显着阻止（p小于或等于0.05）Cd诱导的遗传毒性适应。这强调了除植物螯合素外，蛋白质还可能参与了潜在机制。

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