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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >EFFECT OF CARBOXYMETHYL-CHITIN-GLUCAN ON CYCLOPHOSPHAMIDE INDUCED MUTAGENICITY
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EFFECT OF CARBOXYMETHYL-CHITIN-GLUCAN ON CYCLOPHOSPHAMIDE INDUCED MUTAGENICITY

机译：羧甲基-几丁质-葡聚糖对环磷酰胺致突变性的影响

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The effect of high molecular carboxymethyl-chitin-glucan (CMCG), administered either intraperitoneally, intravenously or orally prior to cyclophosphamide injection, on the frequency of micronucleated reticulocytes was evaluated in peripheral blood of female ICR mice. Both intraperitoneal and intravenous administration of CMCG decreased the clastogenic effect of cyclophosphamide. The protective effect of CMCG was concentration dependent, with a higher decrease achieved by 100 mg/kg than by 50 mg/kg body weight. On the other hand, not even five peroral pretreatments with CMCG in the dose of 200 mg/kg body weight during the week prior to simultaneous administration of CMCG and cyclophosphamide induced a decrease of micronucleated reticulocytes in peripheral blood. It is therefore conceivable that CMCG failed to pass through the gastrointestinal tract, probably due to its high molecular weight. The antimutagenic effect of CMCG against cyclophosphamide was manifested by its intraperitoneal and intravenous administration to female ICR mice.
机译：在雌性ICR小鼠的外周血中，在注射环磷酰胺前腹膜内，静脉内或口服给予高分子量羧甲基-几丁质-葡聚糖（CMCG），以评估其对微核网状细胞频率的影响。腹膜内和静脉内给予CMCG均会降低环磷酰胺的杀乳作用。 CMCG的保护作用是浓度依赖性的，与50 mg / kg体重相比，100 mg / kg的降低幅度更大。另一方面，在同时给予CMCG和环磷酰胺之前的一周中，甚至没有五次以200 mg / kg体重的剂量进行CMCG的经口预处理，导致外周血微核网织红细胞减少。因此，可以想到的是，CMCG可能由于其高分子量而无法通过胃肠道。 CMCG对环磷酰胺的抗诱变作用通过对雌性ICR小鼠进行腹膜内和静脉内给药来体现。

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