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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >NEONATAL VITAMIN K ADMINISTRATION AND IN VIVO SOMATIC MUTATION
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NEONATAL VITAMIN K ADMINISTRATION AND IN VIVO SOMATIC MUTATION

机译：新维生素K的管理和体内体细胞突变

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The glycophorin A (GPA) mutation assay was used to examine the risk of in vivo somatic mutation in infants following neonatal administration of vitamin K. The assay assesses damage to erythroid stem cells by measuring the frequency of NO and NN variant red cells of MN blood group heterozygotes using FAGS analysis. Blood samples were obtained from 178 infants aged between 10 and 183 days. Twenty-six children were excluded from study having received a blood transfusion. Sixty-four of the remaining 152 infants were of the MN phenotype, samples from whom were analysed using the assay system, providing the first data of NO and NN variant frequencies (vfs) in children aged less than 1 year. Twenty of these 64 infants received vitamin K orally (group A), 17 intramuscularly (group B) and 25 intravenously (group C). Results were compared with those from a reference population of children aged 1-15 years. There were no significant differences in NO, NN and total vf between any of groups A, B and C. For all groups both NO and total vf were significantly lower than those for the control population. This result is of some interest and clearly warrants further investigation. NN and total vfs were greater than the 95th percentile for the pooled data from groups A, B and C in three instances, one in each group. It was thus not possible to demonstrate an association between the route of vitamin K administration and an increase in mutation at the GPA locus.
机译：糖蛋白A（GPA）突变试验用于检查新生儿施用维生素K后婴儿体内发生体细胞突变的风险。该试验通过测量MN血液中NO和NN变异红细胞的频率来评估对类红细胞干细胞的损害使用FAGS分析对杂合子进行分组。从178名年龄在10到183天之间的婴儿中获取血液样本。有26名儿童因输血而被排除在研究之外。其余152名婴儿中有64名是MN表型，使用分析系统对其样本进行了分析，从而提供了1岁以下儿童中NO和NN变异频率（vfs）的第一批数据。这64名婴儿中有20名口服维生素K（A组），肌肉注射17种（B组）和静脉注射25种（C组）。将结果与1-15岁儿童的参考人群的结果进行了比较。 A，B和C组之间的NO，NN和总vf均无显着差异。对于所有组，NO和总vf均显着低于对照组。该结果令人感兴趣，并且显然值得进一步研究。在三个实例中，来自A，B和C组的汇总数据的NN和总vfs大于第95个百分点，每组一个。因此，不可能证明维生素K的给药途径与GPA位点突变增加之间的关联。

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