HIGH SPONTANEOUS CHROMOSOMAL DAMAGE IN LYMPHOCYTES FROM PATIENTS WITH HEREDITARY MEGADUODENUM

Doneda L; Basilisco G; Bianchi P; Larizza L

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HIGH SPONTANEOUS CHROMOSOMAL DAMAGE IN LYMPHOCYTES FROM PATIENTS WITH HEREDITARY MEGADUODENUM

机译：遗传性超十二指肠疾病患者淋巴细胞中的高自发性染色体损伤

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Chromosomal aberration and micronucleus assays were used to investigate the extent of cytogenetic damage in peripheral blood lymphocytes from four patients in two unrelated families with hereditary megaduodenum. The frequencies of total chromosomal aberrations, which significantly correlated with those of micronuclei, were higher in the patients than in sex- and age-matched controls, with no overlapping between the two groups. The considerable chromosomal fragility in patients with hereditary megaduodenum may be a genotypic marker for preclinical diagnosis predictive of increased cancer risk.

机译：染色体畸变和微核试验用于研究来自两个不相关家族的遗传性大十二指肠的四名患者外周血淋巴细胞的细胞遗传学损伤程度。与性别和年龄相匹配的对照组相比，患者中的总染色体畸变的频率与微核的频率显着相关，且两组之间没有重叠。遗传性十二指肠患者相当大的染色体脆性可能是临床前诊断的基因型标记，可预测增加的癌症风险。

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《Mutation Research, C. Mutation Research Letters》 |1995年第1期|共4页
作者
Doneda L; Basilisco G; Bianchi P; Larizza L;
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正文语种 eng
中图分类遗传学;
关键词
Hereditary megaduodenum; Chromosomal damage; Cancer risk; Intestinal pseudo obstruction; Hollow visceral myopathy;

机译：遗传性大十二指肠;染色体损伤;癌症风险;肠假性梗阻;空心内脏肌病;

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专利

1. HIGH SPONTANEOUS CHROMOSOMAL DAMAGE IN LYMPHOCYTES FROM PATIENTS WITH HEREDITARY MEGADUODENUM [J] . Doneda L, Basilisco G, Bianchi P, Mutation Research, C. Mutation Research Letters . 1995,第1期

机译：遗传性超十二指肠疾病患者淋巴细胞中的高自发性染色体损伤
2. Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients [J] . Andrea Hille, Hana Hofman-Hiither, Elna Kiihnle Radiation and Environmental Biophysics . 2010,第1期

机译：前列腺癌患者淋巴细胞放射治疗后自发和辐射诱发的染色体不稳定和染色体畸变的持久性
3. Analysis of spontaneous and bleomycin-induced chromosome damage in peripheral lymphocytes of long-haul aircrew members from Argentina. [J] . Bolzan AD, Bianchi MS, Gimenez EM, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2008,第1a2期

机译：来自阿根廷的长途机组人员外周淋巴细胞自发性和博来霉素诱导的染色体损伤分析。
4. Association Study of the Frequencies of Spontaneous and Induced Chromosome Aberrations in Human Lymphocytes [C] . Luybov Salnikova, Anastasia Chumachenko, Alexander V. Rubanovich NATO Advanced Research Workshop on Radiological Issues Pertaining to Environmental Security and Ecoterrorism . 2012

机译：人淋巴细胞自发性诱导染色体畸变的频率研究
5. Investigating chromosome damage and gammaH2AX response in human lymphocytes and lymphocyte subsets as potential biomarkers of radiation sensitivity. [D] . Beaton, Lindsay A. 2013

机译：研究人类淋巴细胞和淋巴细胞亚群中的染色体损伤和gammaH2AX反应，作为辐射敏感性的潜在生物标记。
6. Spontaneous chromosomal instability in peripheral blood lymphocytesfrom two molecularly confirmed Italian patients with Hereditary FibrosisPoikiloderma: insights into cancer predisposition [O] . Gaia Roversi, Elisa Adele Colombo, Ivana Magnani, 2021

机译：外周血淋巴细胞中的自发染色体不稳定性从两个分子证实的意大利遗传性纤维化患者Poikiloderma：洞察癌症易感性
7. Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients [O] . Andrea Hille, Hana Hofman-Hüther, Elna Kühnle, 2009

机译：前列腺癌患者淋巴细胞放射治疗后自发和辐射诱发的染色体不稳定和染色体畸变的持久性
8. Distributions of spontaneous chromosomal aberrations and of spontaneous and induced SCE and micronuclei in peripheral lymphocytes from a human population [R] . Bender, MA, Setlow, R B 1992

机译：人群外周血淋巴细胞中自发染色体畸变和自发和诱导的sCE和微核的分布

HIGH SPONTANEOUS CHROMOSOMAL DAMAGE IN LYMPHOCYTES FROM PATIENTS WITH HEREDITARY MEGADUODENUM

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