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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >Comparison of sister chromatid exchange frequency in peripheral lymphocytes in lung cancer cases and controls
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Comparison of sister chromatid exchange frequency in peripheral lymphocytes in lung cancer cases and controls

机译：肺癌病例与对照组外周血淋巴细胞姐妹染色单体交换频率的比较

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摘要

Cytogenctic alterations have been associated with the occurrence of many cancers, However, limited data exist to address whether increased chromosomal changes in surrogate normal tissue are similarly associated with malignancy, As part of an ongoing case-control study of lung cancer, we have studied the factors that affect sister chromatid exchange (SCE) frequency in lymphocytes from lung cancer patients. Further, we sought to investigate whether the factors that affect SCE frequencies were comparable in lung cancer cases and controls. Cases had newly diagnosed, operable primary lung cancer. Controls were friends and spouses of cases. Detailed information on smoking, family history of cancer, medical history, and unvironmcntal and occupational exposures was obtained in an interviewer-administered questionnaire. Intake of antioxidants was also determined through the administration of a validated semiquantitative food frequency questionnaire. Metabolic traits studied included the polymorphic glutathione-S-transferasc class mu (GST-mu) and variants of P450 isoenzymes CYP1A1 and CYP 2D6. Overall, 78 cases and 78 controls were included in the analysis. Although there was a small number of lung cancer patients who had never smoked in the study (9% of cases), these patients had higher SCE frequencies than current or former smokers. This suggests that factors associated with gcnomic instability may also play a role in the pathogenesis of lung cancer. The best fit model for SCE frequency, which had been previously generated from control data alone, included age, gender, smoking, GST-mu, and vitamin A intake. However, when this model was applied to lung cancer patients, smoking was not associated with an elevated SCE frequency. Thus, it is not clear thatSCE frequency data in prevalent lung cancer cases and controls arc comparable.
机译：细胞凋亡的改变与许多癌症的发生有关，但是，目前仅有有限的数据来解决替代正常组织中染色体变化的增加是否与恶性肿瘤相关。作为正在进行的肺癌病例对照研究的一部分，我们对肺癌进行了研究。影响肺癌患者淋巴细胞姐妹染色单体交换（SCE）频率的因素。此外，我们试图调查影响SCE频率的因素在肺癌病例和对照中是否具有可比性。病例有新诊断的可手术原发性肺癌。控制对象是案件的朋友和配偶。有关吸烟，癌症家族病史，病史以及非环境和职业暴露的详细信息，可通过访调员管理的调查表获得。抗氧化剂的摄入量也通过管理有效的半定量食物频率调查问卷来确定。研究的代谢性状包括多态性谷胱甘肽-S-转移酶类mu（GST-mu）和P450同工酶CYP1A1和CYP 2D6的变体。总体而言，分析中包括78例病例和78例对照。尽管在研究中有极少数从未吸烟的肺癌患者（占病例的9％），但这些患者的SCE频率高于目前或以前的吸烟者。这表明与基因组不稳定性相关的因素也可能在肺癌的发病机理中起作用。 SCE频率的最佳拟合模型（以前仅从控制数据中得出）包括年龄，性别，吸烟，GST-mu和维生素A摄入量。但是，当此模型应用于肺癌患者时，吸烟与SCE频率升高无关。因此，尚不清楚在流行的肺癌病例和对照中，SCE频率数据是否具有可比性。

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