MUTAGENICITY AND CLASTOGENICITY OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) IN L5178Y/TK+/--3.7.2C MOUSE LYMPHOMA CELLS

Harringtonbrock K; Doerr CL; Moore MM

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MUTAGENICITY AND CLASTOGENICITY OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) IN L5178Y/TK+/--3.7.2C MOUSE LYMPHOMA CELLS

机译：L5178Y / TK + /-3.7.2C小鼠淋巴瘤细胞中3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的致突变性

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3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was tested without exogenous activation in L5178Y/TK+/--3.7.2C mouse lymphoma cells for mutation at the thymidine kinase locus and for clastogenicity. At a concentration of 0.75 mu g/ml, the induced mutant frequency was 1027 per 10(6) survivors (survival=11%). A concentration-related increase of large and small colony mutants was observed, but the majority of the MX induced mutants formed small colonies, consistent with the positive clastogenic response that was observed. MX primarily induced chromatid breaks and rearrangements (30 chromatid and 4 chromosome aberrations per 100 cells) at the 0.75 mu g/ml dose. These studies indicate that MX induces a broad spectrum of genetic damage.

机译：在L5178Y / TK + /-3.7.2C小鼠淋巴瘤细胞中测试了3-chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）在没有外源激活的情况下在胸苷激酶基因座处的突变以及致裂性。在0.75μg / ml的浓度下，诱导的突变频率为每10（6）个幸存者1027个（生存= 11％）。观察到了与浓度相关的大，小菌落突变体的增加，但是大多数MX诱导的突变体形成了小菌落，这与观察到的阳性致胶体反应一致。 MX主要以0.75μg / ml的剂量诱导染色单体断裂和重排（每100个细胞30个染色单体和4个染色体畸变）。这些研究表明，MX诱导了广泛的遗传损伤。

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《Mutation Research, C. Mutation Research Letters》 |1995年第3期|共6页
作者
Harringtonbrock K; Doerr CL; Moore MM;
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正文语种 eng
中图分类遗传学;
关键词
Chlorination byproduct; Chromosome aberration; Gene mutation; Mouse; Potent bacterial mutagen; Drinking water; Sister chromatids; Tk; Invitro; Invivo;

机译：氯化副产物;染色体畸变;基因突变;小鼠;强力细菌诱变剂;饮用水;姐妹染色单体;Tk;体外;体内;

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1. MUTAGENICITY AND CLASTOGENICITY OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) IN L5178Y/TK+/--3.7.2C MOUSE LYMPHOMA CELLS [J] . Harringtonbrock K, Doerr CL, Moore MM Mutation Research, C. Mutation Research Letters . 1995,第3期

机译：L5178Y / TK + /-3.7.2C小鼠淋巴瘤细胞中3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的致突变性
2. Detection of in vivo genotoxicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) by the alkaline single cell gel electrophoresis (Comet) assay in multiple mouse organs. [J] . Sasaki YF, Nishidate E, Izumiyama F, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1997,第1a2期

机译：通过碱性单细胞凝胶电泳（Comet）测定在多个小鼠器官中检测3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的体内遗传毒性。
3. Food-derived heterocyclic amines potentiate the mutagenicity of a drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX). [J] . Watanabe Akanuma M, Shimoi K, Kinae N, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1997,第2期

机译：食物衍生的杂环胺可增强饮用水中的诱变剂3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的诱变性。
4. Pilot-plant study of the formaiton of the disinfection by-product 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in dinking water [C] . C.J.Hwang, S.W.Krasner, S.A.Andrews, Ozonation for drinking water treatment . 1992

机译：在饮用水中形成消毒副产物3-氯-4-（氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的中试研究
5. Removal of 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone (MX) Precursors during Water Treatment Biofiltration [D] . Mian, Noreen 2018

机译：水处理生物过滤过程中去除3-氯-4-二氯甲基-5-羟基-2（5H）-呋喃酮（MX）前体
6. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. [O] . J Michael Wright, Joel Schwartz, Terttu Vartiainen, 2002

机译：马萨诸塞州饮用水中的3-Chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）和诱变活性。
7. Experimental studies on cellular mechanisms of the carcinogenecity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) (Kokeellisia tutkimuksia 3-kloori-4-(dikloorimetyyli)-5-hydroksi-2(5H)-furanonin (MX) karsinogeenisuuden solutason mekanismeista) [O] . Hakulinen Pasi 100

机译：3-氯-4-（二氯甲基）-5-羟基-2（5H） - 呋喃酮（mX）致癌性的实验研究（3-氯-4-（二氯甲基）-5-羟基-2的实验研究）（5H） - 呋喃酮（mX）致癌性的细胞机制）
8. Mutagenic and Clastogenic Properties of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone: A Potent Bacterial Mutagen in Drinking Water [R] . Meier, J. R. , Blazak, W. F. , Knohl, R. B. 1987

机译：3-氯-4-（二氯甲基）-5-羟基-2（5H） - 呋喃酮的诱变和致裂特性：饮用水中的强效细菌诱变剂

MUTAGENICITY AND CLASTOGENICITY OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) IN L5178Y/TK+/--3.7.2C MOUSE LYMPHOMA CELLS

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