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Pitfalls of enzyme-based molecular anticancer dietary manipulations: food for thought

机译:基于酶的分子抗癌饮食控制的陷阱:值得深思的地方

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摘要

Dietary approaches to cancer chemoprevention increasingly have focused on single nutrients or phytochemicals to stimulate one or another enzymatic metabolizing system. These procedures, which aim to boost carcinogen detoxification or inhibit carcinogen bioactivation, fail to take into account the multiple and paradoxical biological outcomes of enzyme modulators that make their effects unpredictable. Here, we critically examine the scientific and medical evidence for the idea that the physiological roles of specific enzymes may be manipulated by regular, long-term administration of isolated nutrients and other chemicals derived from food plants. Instead, we argue that consumption of healthful diets is most likely to reduce mutagenesis and cancer risk, and that research efforts and dietary recommendations should be redirected away from single nutrients to emphasize the improvement of dietary patterns as a principal strategy for public health policy.
机译:饮食中化学预防癌症的方法越来越集中于单一营养素或植物化学物质,以刺激一种或另一种酶促代谢系统。这些旨在促进致癌物解毒或抑制致癌物生物激活的程序,没有考虑到酶调节剂的多重和自相矛盾的生物学结果,这些结果使酶调节剂的作用不可预测。在这里,我们批判性地检查科学和医学证据,以为特定酶的生理作用可以通过定期,长期管理分离的营养物质和食用植物衍生的其他化学物质来操纵。相反,我们认为食用健康饮食最有可能减少诱变和癌症风险,并且应该将研究工作和饮食建议从单一营养素中转移出来,以强调改善饮食习惯作为公共卫生政策的主要策略。

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