GENOTOXICITY OF POLYCHLORINATED BIPHENYLS (PCBS) - RECOMBINOGENESIS BY BIOTRANSFORMATION PRODUCTS

Butterworth FM; Pandey P; Mcgowen RM; Alisadat S; Walia S

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GENOTOXICITY OF POLYCHLORINATED BIPHENYLS (PCBS) - RECOMBINOGENESIS BY BIOTRANSFORMATION PRODUCTS

机译：多氯联苯（PCBS）的遗传毒性-通过生物转化产物重组

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A coplanar polychlorinated biphenyl (PCB) when eaten by test animals increased the rate of recombination in somatic cells, indicating a new mechanism of action for these compounds. Using the eye-mosaic test a high bioactivation strain of Drosophila that consumed 4,4'-dichlorobiphenyl (4,4'-DCB) manifested a genotoxicity rate that was three-fold greater than that in animals fed the solvent-spiked medium. This compound was not genotoxic in a suppressed bioactivation strain indicating that genotoxicity requires bioactivation of the compound. High bioactivation test strains made heterozygous for a paracentric inversion, a chromosomal rearrangement that suppresses homologous recombination, exhibited significantly reduced genotoxicity after treatment.

机译：当被实验动物食用时，共面多氯联苯（PCB）会增加体细胞中的重组速率，这表明这些化合物具有新的作用机理。使用眼马赛克测试，果蝇的高生物活性菌株消耗了4,4'-二氯联苯（4,4'-DCB），其遗传毒性比喂食溶剂加溶剂培养基的动物高三倍。该化合物在抑制的生物活化菌株中没有遗传毒性，表明遗传毒性需要化合物的生物活化。高生物激活测试菌株使杂合子成为副中心倒置，抑制同源重组的染色体重排，在治疗后遗传毒性显着降低。

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《Mutation research. Genetic toxicology testing》 |1995年第2期|共9页
作者
Butterworth FM; Pandey P; Mcgowen RM; Alisadat S; Walia S;
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正文语种 eng
中图分类遗传学;
关键词
Recombination; Polychlorinated biphenyl; Metabolite; Drosophila; Drosophila melanogaster; Mutagenicity test; Metabolites; 2; 2'; 5; 5' tetrachlorobiphenyl; Recombination; Mechanisms; Salmonella; Mutation; Damage;

机译：重组;多氯联苯;代谢产物;果蝇;黑腹果蝇;致突变性试验;代谢产物;2;2';5;5'四氯联苯;重组;机理;沙门氏菌;突变;损伤;

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专利

1. GENOTOXICITY OF POLYCHLORINATED BIPHENYLS (PCBS) - RECOMBINOGENESIS BY BIOTRANSFORMATION PRODUCTS [J] . Butterworth FM, Pandey P, Mcgowen RM, Mutation research. Genetic toxicology testing . 1995,第1a2期

机译：多氯联苯（PCBS）的遗传毒性-通过生物转化产物重组
2. Polychlorinated dioxins, furans (PCDD/Fs), dioxin-like polychlorinated biphenyls (dl-PCBs) and indicator PCBs (ind-PCBs) in egg and egg products in Turkey [J] . Burcu Olanca, Gul Celik Cakirogullari, Yunus Ucar, Chemosphere . 2014,第jana期

机译：鸡蛋和蛋制品中的多氯二恶英，呋喃（PCDD / Fs），类二恶英类多氯联苯（dl-PCBs）和指示剂PCB（ind-PCBs）
3. Human dietary exposure and levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like polychlorinated biphenyls (DL-PCBs) and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) in free-range eggs close to a secondary aluminum smelter, Northern Italy (vol 205, pg 429, 2015) [J] . Squadrone S., Brizio P., Nespoli R., Environmental Pollution . 2016,第JANaPTaB期

机译：人类饮食中散养鸡蛋中的食物摄入量以及多氯联苯对二恶英（PCDDs），多氯联苯二呋喃（PCDF），类二恶英类多氯联苯（DL-PCBs）和类非二恶英类多氯联苯（NDL-PCBs）的水平意大利北部，靠近一家二级铝冶炼厂（2015年，第205卷，第429页）
4. Inadvertent Polychlorinated Biphenyls (PCBs) in Consumer Products [C] . Liu X, Muffin M Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2019

机译：消费品中的无意多氯联苯（PCB）
5. Rhizosphere biotransformation of selected polychlorinated biphenyl (PCB) congeners by switchgrass and poplar [D] . Meggo, Richard Edward 2012

机译：柳枝switch和杨树对选定多氯联苯（PCB）同类物的根际生物转化
6. Rhizospere Redox Cycling and Implications for Rhizosphere Biotransformation of Selected Polychlorinated Biphenyl (PCB) Congeners [O] . Richard E. Meggo, Jerald L. Schnoor -1

机译：根茎生物的氧化还原循环及其对选定多氯联苯（PCB）同类物的根际生物转化的意义
7. Tracing the biotransformation of polychlorinated biphenyls (PCBs) in common carp (Cryprinus carpio): Enantiomeric fraction and compound-specific stable carbon isotope analyses [O] . Tang Bin, Luo Xiao-Jun, Zeng Yan-Hong, 2016

机译：追踪鲤鱼（Cryprinus carpio）中多氯联苯（PCB）的生物转化：对映体馏分和化合物特异性稳定碳同位素分析

GENOTOXICITY OF POLYCHLORINATED BIPHENYLS (PCBS) - RECOMBINOGENESIS BY BIOTRANSFORMATION PRODUCTS

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