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首页> 外文期刊>Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects >Seasonal variability of oxidative stress markers in city bus drivers. Part I. Oxidative damage to DNA.
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Seasonal variability of oxidative stress markers in city bus drivers. Part I. Oxidative damage to DNA.

机译：城市公交车驾驶员氧化应激指标的季节性变化。第一部分：对DNA的氧化损伤。

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摘要

We investigated the seasonal variability of 8-oxodeoxyguanosine (8-oxodG), a marker of oxidative damage to DNA, in urine of 50 bus drivers and 50 controls in Prague, Czech Republic, in three seasons with different levels of air pollution: winter 2005, summer 2006 and winter 2006. The exposure to environmental pollutants (carcinogenic polycyclic aromatic hydrocarbons, c-PAHs, particulate matter (PM), and volatile organic compounds (VOC)) was monitored by personal and/or stationary monitors. For the analysis of 8-oxodG levels, the ELISA technique was used. Bus drivers were exposed to significantly higher levels of c-PAHs in winter 2006, while in the other two seasons the exposure of controls was unexpectedly higher than that of bus drivers. We did not see any difference in VOC exposure between both groups in summer 2006 and in winter 2006; VOC were not monitored in winter 2005. 8-OxodG levels were higher in bus drivers than in controls in all seasons. The median levels of 8-oxodG (nmol/mmol creatinine) in bus drivers vs. controls were as follows: winter 2005: 7.79 vs. 6.12 (p=0.01); summer 2006: 6.91 vs. 5.11 (p0.01); winter 2006: 5.73 vs. 3.94 (p0.001). Multivariate logistic regression analysis identified PM2.5 and PM10 levels, measured by stationary monitors during a 3-day period before urine collection, as the only factors significantly affecting 8-oxodG levels, while the levels of c-PAHs had no significant influence.
机译：我们调查了捷克共和国布拉格的50名公交驾驶员和50名对照的尿液在三个不同空气污染水平的季节中的8个季节对8氧脱氧鸟嘌呤（8-oxodG）的季节性变化的影响，该尿液的浓度分别为2005年冬季，分别于2006年夏季和2006年冬季进行。个人和/或固定监测器监测了环境污染物（致癌多环芳烃，c-PAHs，颗粒物（PM）和挥发性有机化合物（VOC））的暴露。为了分析8-oxodG水平，使用了ELISA技术。 2006年冬季，公交车司机接触到c-PAHs的水平明显升高，而在其他两个季节中，控制人员的接触却出乎意料地高于公交车司机。在2006年夏季和2006年冬季，两组之间的VOC暴露均没有差异。 2005年冬季未对VOC进行监控。在所有季节中，公交车司机的8-OxodG水平均高于对照组。公交车司机相对于对照组的8-oxodG（nmol / mmol肌酐）的中位数水平如下：2005年冬季：7.79 vs.6.12（p = 0.01）; 2006年夏季：6.91比5.11（p <0.01）; 2006年冬季：5.73比3.94（p <0.001）。多元逻辑回归分析确定，在收集尿液之前的三天内，由固定监测仪测量的PM2.5和PM10水平是显着影响8-oxodG水平的唯一因素，而c-PAHs水平没有显着影响。

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