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首页> 外文期刊>Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects >Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking.
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Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking.

机译：研究印度健康男性人口的T淋巴细胞中HPRT突变体频率与年龄和吸烟的关系。

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摘要

Mutant frequency at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in the peripheral blood lymphocytes obtained from 44 healthy individuals (23 non-smokers and 21 smokers) of an Indian male population was studied using T-lymphocyte cloning assay. It was found that lnMF increased with age at a rate of 2.5% per year (P < 0.001). Blood samples from smokers showed a significant (P < 0.037) increase in HPRT mutant frequency (MF) (10.43 +/- 4.74 x 10(-6)) as compared to that obtained from non-smokers (7.69 +/- 3.69 x 10(-6)). This study also showed a significant (P < 0.027) inverse correlation between lnMF and non-selected cloning efficiency (CE). However, with respect to age no variation was observed in cloning efficiency. The results obtained in this study showed a good comparison with those reported in different populations of the world.
机译：使用T淋巴细胞克隆试验研究了从印度男性人群的44位健康个体（23位非吸烟者和21位吸烟者）获得的外周血淋巴细胞中的次黄嘌呤-鸟嘌呤磷酸核糖基转移酶（HPRT）基因的突变频率。发现lnMF随着年龄的增长以每年2.5％的速度增长（P <0.001）。与非吸烟者的血样（7.69 +/- 3.69 x 10）相比，吸烟者的血样显示HPRT突变频率（MF）显着增加（P <0.037）（10.43 +/- 4.74 x 10（-6））。 （-6））。这项研究还表明，lnMF与非选择克隆效率（CE）之间存在显着的（P <0.027）负相关。但是，关于年龄，克隆效率没有变化。这项研究获得的结果与世界上不同人群的报道有很好的比较。

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