A shared surface of TBP directs RNA polymerase II and III transcription via association with different TFIIB family members.

Zhao X; Schramm L; Hernandez N; Herr W

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A shared surface of TBP directs RNA polymerase II and III transcription via association with different TFIIB family members.

机译：TBP的共享表面通过与不同的TFIIB家族成员缔合来指导RNA聚合酶II和III转录。

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The TATA box binding protein TBP is highly conserved and the only known basal factor that is involved in transcription by all three eukaryotic nuclear RNA polymerases from promoters with or without a TATA box. By mutagenesis and analysis on a selected set of four model pol II and pol III TATA box-containing and TATA-less promoters, we demonstrate that human TBP utilizes two modes to achieve its versatile functions. First, it uses a different set of surfaces on the conserved and structured TBP core domain to direct transcription from each of the four model promoters. Second, unlike yeast TBP, human TBP can use a shared surface to interact with two different TFIIB family members--TFIIB and Brf2--to initiate transcription by different RNA polymerases.

机译：TATA盒结合蛋白TBP是高度保守的，并且是唯一已知的基础因子，其涉及所有三种真核核RNA聚合酶从具有或不具有TATA盒的启动子中转录。通过诱变和分析选定的四个模型pol II和pol III TATA框包含和不含TATA的启动子集，我们证明了人类TBP利用两种模式来实现其通用功能。首先，它在保守和结构化的TBP核心结构域上使用了一组不同的表面来指导从四个模型启动子中的每一个转录。其次，与酵母TBP不同，人TBP可以使用共享的表面与两个不同的TFIIB家族成员TFIIB和Brf2-相互作用，以通过不同的RNA聚合酶引发转录。

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《Molecular cell》 |2003年第1期|共11页
作者
Zhao X; Schramm L; Hernandez N; Herr W;
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正文语种 eng
中图分类分子生物学;细胞生物学;
关键词
RNA Polymerase II; RNA Polymerase III; TATA-Box Binding Protein; Transcription Factor TFIIB; RNA聚合酶Ⅱ; RNA聚合酶Ⅲ;

机译：RNA Polymerase II;RNA Polymerase III;TATA-Box Binding Protein;Transcription Factor TFIIB;RNA聚合酶Ⅱ;RNA聚合酶Ⅲ;

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专利

1. A shared surface of TBP directs RNA polymerase II and III transcription via association with different TFIIB family members. [J] . Zhao X, Schramm L, Hernandez N, Molecular cell . 2003,第1期

机译：TBP的共享表面通过与不同的TFIIB家族成员缔合来指导RNA聚合酶II和III转录。
2. Human Maf1 negatively regulates RNA Polymerase III transcription via the TFIIB family members Brf1 and Brf2 [J] . Janet Rollins, Ingrid Veras, Stephanie Cabarcas, International journal of biological sciences . 2007,第5期

机译：人类Maf1通过TFIIB家族成员Brf1和Brf2负调控RNA聚合酶III转录
3. The TFIIE-related Rpc82 subunit of RNA polymerase III interacts with the TFIIB-related transcription factor Brf1 and the polymerase cleft for transcription initiation [J] . Khoo Seok-Kooi, Wu Chih-Chien, Lin Yu-Chun, Nucleic Acids Research . 2018,第3期

机译：RNA聚合酶III的TFIIE相关的RPC82亚基与TFIIB相关转录因子BRF1和用于转录起始的聚合酶裂隙相互作用
4. Modulation of RNA polymerase core functions by basal transcription factor TFB/TFIIB [C] . Finn Werner, Simone Wiesler, Sven Nottebaum Biochemical Society Symposium . 2006

机译：通过基础转录因子TFB / TFIIB调节RNA聚合酶核心功能
5. Genetic and biochemical analysis of the role of TBP associated factors in RNA polymerase II dependent gene transcription in the yeast Saccharomyces cerevisiae [D] . Sanders, Steven Lee 2000

机译：TBP相关因子在酿酒酵母中RNA聚合酶II依赖性基因转录中的作用的遗传和生化分析
6. TATA box-binding protein (TBP) is a constituent of the polymerase I-specific transcription initiation factor TIF-IB (SL1) bound to the rRNA promoter and shows differential sensitivity to TBP-directed reagents in polymerase I II and III transcription factors. [O] . C A Radebaugh, J L Matthews, G K Geiss, 1994

机译：TATA盒结合蛋白（TBP）是与rRNA启动子结合的聚合酶I特异性转录起始因子TIF-IB（SL1）的组成部分在聚合酶III和III转录因子中对TBP定向试剂表现出不同的敏感性。
7. TATA box-binding protein (TBP) is a constituent of the polymerase I-specific transcription initiation factor TIF-IB (SL1) bound to the rRNA promoter and shows differential sensitivity to TBP-directed reagents in polymerase I, II, and III transcription factors. [O] . Radebaugh, C A, Matthews, J L, Geiss, G K, 1994

机译：TATA盒结合蛋白（TBP）是与rRNA启动子结合的聚合酶I特异性转录起始因子TIF-IB（SL1）的组成部分，在聚合酶I，II和III转录因子中对TBP定向试剂表现出不同的敏感性。

A shared surface of TBP directs RNA polymerase II and III transcription via association with different TFIIB family members.

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