An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication.

Costanzo V; Shechter D; Lupardus PJ; Cimprich KA; Gottesman M; Gautier J

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An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication.

机译：ATR和Cdc7依赖性DNA损伤检查点，可抑制DNA复制的启动。

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We have analyzed how single-strand DNA gaps affect DNA replication in Xenopus egg extracts. DNA lesions generated by etoposide, a DNA topoisomerase II inhibitor, or by exonuclease treatment activate a DNA damage checkpoint that blocks initiation of plasmid and chromosomal DNA replication. The checkpoint is abrogated by caffeine and requires ATR, but not ATM, protein kinase. The block to DNA synthesis is due to inhibition of Cdc7/Dbf4 protein kinase activity and the subsequent failure of Cdc45 to bind to chromatin. The checkpoint does not require pre-RC assembly but requires loading of the single-strand binding protein, RPA, on chromatin. This is the biochemical demonstration of a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase.

机译：我们分析了单链DNA缺口如何影响非洲爪蟾卵提取物中的DNA复制。依托泊苷，DNA拓扑异构酶II抑制剂或核酸外切酶处理产生的DNA损伤激活了DNA损伤检查点，从而阻止了质粒和染色体DNA复制的启动。该检查点被咖啡因废除，需要ATR，但不需要ATM蛋白激酶。 DNA合成受阻是由于抑制了Cdc7 / Dbf4蛋白激酶活性，以及随后的Cdc45与染色质结合失败。该检查点不需要RC前组装，但需要在染色质上加载单链结合蛋白RPA。这是针对Cdc7 / Dbf4蛋白激酶的DNA损伤检查点的生化演示。

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《Molecular cell》 |2003年第1期|共11页
作者
Costanzo V; Shechter D; Lupardus PJ; Cimprich KA; Gottesman M; Gautier J;
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正文语种 eng
中图分类分子生物学;细胞生物学;
关键词
DNA Replication; DNA Damage; Cognitive function: initiation; Dbf4 protein; DNA复制; DNA损伤;

机译：DNA Replication;DNA Damage;Cognitive function: initiation;Dbf4 protein;DNA复制;DNA损伤;

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1. An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication. [J] . Costanzo V, Shechter D, Lupardus PJ, Molecular cell . 2003,第1期

机译：ATR和Cdc7依赖性DNA损伤检查点，可抑制DNA复制的启动。
2. An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage [J] . Timothy P. Heffernan, Dennis A. Simpson, Alexandra R. Frank, Molecular and Cellular Biology . 2002,第24期

机译：ATR和依赖Chk1的S检查点抑制UVC诱导的DNA损伤后复制子的起始
3. An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage [J] . Timothy P. Heffernan, Dennis A. Simpson, Alexandra R. Frank, Molecular and Cellular Biology . 2002,第24期

机译：ATR和依赖Chk1的S检查点抑制UVC诱导的DNA损伤后复制子的起始
4. BLIND SPOT OF G1/S CHECKPOINT: G1/S CHECKPOINT IS INVADED BY DNA-DAMAGE AFTER R-POINT [C] . International Association of Science and Technology for Development international conference on intelligent systems and control . 2008

机译：G1 / S检查点的盲点：r点后的DNA损坏侵入G1 / S检查点
5. Telomere maintenance by DNA damage checkpoint and DNA repair proteins in Schizosaccharomyces pombe [D] . Subramanian, Lakxmi 2010

机译：粟酒裂殖酵母DNA损伤检查点和DNA修复蛋白对端粒的维护
6. An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage [O] . Timothy P. Heffernan, Dennis A. Simpson, Alexandra R. Frank, 2002

机译：ATR和依赖Chk1的S检查点抑制UVC诱导的DNA损伤后复制子的起始
7. An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage [O] . Heffernan, Timothy P., Simpson, Dennis A., Frank, Alexandra R., 2002

机译：ATR和依赖Chk1的S检查点抑制UVC诱导的DNA损伤后复制子的起始
8. Role of Rad17 in DNA Damage Checkpoint Signaling and Initiation of Apoptosis in Mammary Cells [R] . Jian, H. 2005

机译：Rad17在乳腺癌细胞DNa损伤检测点信号传导和细胞凋亡中的作用

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication.

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