5-Fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.

Wellington M; Kabir M A; Rustchenko E

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5-Fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.

机译：5-氟乳清酸诱导基因改造的白色念珠菌菌株中的染色体改变。

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We previously reported the occurrence of chromosome alterations in a Candida albicans prototrophic strain 3153A treated with 5-fluoro-orotic acid (5-FOA). In this study we investigated the mutagenic properties of 5-FOA with two derivatives of C. albicans strain CAF4-2 (ura3/ura3), each containing an ectopic copy of URA3 gene (ura3/ura3 URA3) on a different chromosome. As expected, after the ura3/ura3 URA3 constructs were applied to 5-FOA containing solid medium, the "pop-outs" that lost URA3 appeared. However most of the "pop-outs" acquired various chromosome alterations. Thus constructs exposed to 5-FOA should be examined for chromosome alterations or the use of 5-FOA should be avoided..

机译：我们以前曾报道过用5-氟乳清酸（5-FOA）处理的白色念珠菌原营养菌株3153A中发生了染色体改变。在这项研究中，我们调查了白色念珠菌CAF4-2菌株（ura3 / ura3）的两种衍生物对5-FOA的诱变特性，每种衍生物在不同染色体上都包含URA3基因的异位拷贝（ura3 / ura3 URA3）。不出所料，将ura3 / ura3 URA3构建体应用于含5-FOA的固体培养基后，出现了丢失URA3的“弹出”现象。然而，大多数“弹出”获得了各种染色体改变。因此，应检查暴露于5-FOA的构建体的染色体变化，或应避免使用5-FOA。

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《Mycologia》 |2006年第3期|共6页
作者
Wellington M; Kabir M A; Rustchenko E;
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原文格式 PDF
正文语种 eng
中图分类 Q939.5;
关键词
candidosis; chromosome aberrations; chromosomes; mutagenicity; strains;

机译：念珠菌病;染色体畸变;染色体;诱变性;毒株;

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1. 5-Fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans. [J] . Wellington M, Kabir M A, Rustchenko E Mycologia . 2006,第3期

机译：5-氟乳清酸诱导基因改造的白色念珠菌菌株中的染色体改变。
2. 5-Fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans. [J] . Wellington M, Kabir M A, Rustchenko E Mycologia . 2006,第3期

机译：5-氟乳清酸诱导基因改造的白色念珠菌菌株中的染色体改变。
3. 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans [J] . Wellington M, Rustchenko E Yeast . 2005,第1期

机译：5-氟乳清酸诱导白色念珠菌的染色体改变
4. Clinical Significance of Genetic Alterations of Chromosome 3,7,X and EGFR Gene in Uterine Cervical Cancer Progression [C] . AM. Cianciulli, G. Corrado, R. Merola, International Multidisciplinary Congress . 2003

机译：子宫宫颈癌进展中染色体3,7，X和EGFR基因遗传改变的临床意义
5. Analysis of the role of the major repeat sequence in chromosome dynamics in Candida albicans. [D] . Lephart, Paul Robert. 2006

机译：主要重复序列在白色念珠菌染色体动力学中的作用分析。
6. Chromosomal rearrangements associated with morphological mutants provide a means for genetic variation of Candida albicans. [O] . E P Rustchenko-Bulgac, F Sherman, J B Hicks 1990

机译：与形态突变相关的染色体重排为白色念珠菌的遗传变异提供了一种手段。
7. A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans. [O] . Gomes, AC, Miranda, I, Silva, RM, 2007

机译：遗传密码的改变在人类病原体白色念珠菌中产生了高度多样性的蛋白质组。
8. Physiology and Molecular-Genetics of 'Thermus' and 'Bacillus'. 6. TemperatureInduced Alterations in the Fatty Acid Composition of Wild Type and Plasmid-Cured 'Thermus' Strains [R] . Norstroem, K. M., Rudolf, S. E., Virtala, M. K. 1993

机译：'Thermus'和'Bacillus'的生理学和分子遗传学。 6.温度诱导野生型和质粒固化'Thermus'菌株脂肪酸组成的变化

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5-Fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.

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