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Distribution and bioinformatic analysis of the cerato-platanin protein family in Dikarya

机译：迪卡里亚地区cerato-platanin蛋白家族的分布和生物信息学分析

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The cerato-platanin family is a group of small cysteine-rich fungal proteins new to science. They usually are abundantly secreted extracellularly and are involved in fungus-host interactions. With the advance of available fungal genome sequences, we performed a genomewide study of the distribution of this family in fungi and analyzed the common characteristics of the protein sequences. A total of 55 fungal genomes, including 27 from Ascomycota and 28 from Basidiomycota, were used. A total of 130 cerato-platanin homolog protein sequences were obtained and analyzed. Our results showed that cerato-platanin homologs existed in both Ascomycota and Basidiomycota but were lost in early branches of jelly fungi as well as in some groups with yeast or yeast-like forms in their life cycle. Homolog numbers varied considerably between Ascomycota and Basidiomycota. Phylogenetic analysis suggested that the ancestor of the Dikarya possessed multiple copies of cerato-platanins, which sorted differently in Ascomycota and Basidiomycota, and that this gene family might have expanded in the Basidiomycota. Almost all homologs contained signal peptide sequences, and the length of mature proteins were mainly 105-134 amino acids. Four cysteines involved in forming two disulfide bridges and signature sequences (CSD or CSN) were highly conserved in most homologs. These results indicated a higher diversity of the cerato-platanin family in Basidiomycota than Ascomycota.
机译：cerato-platanin家族是一组新发现的富含小半胱氨酸的真菌蛋白。它们通常在细胞外大量分泌，并参与真菌-宿主相互作用。随着可用真菌基因组序列的发展，我们进行了该家族在真菌中分布的全基因组研究，并分析了蛋白质序列的共同特征。总共使用了55个真菌基因组，包括来自子囊菌的27个和来自担子菌的28个。总共获得并分析了130个cerato-platanin同源蛋白序列。我们的结果表明，在子囊菌和担子菌菌中均存在cerato-platanin同源物，但在果冻真菌的早期分支中以及在生命周期中以酵母或类酵母形式存在的某些组中都丢失了。子囊菌和担子菌菌落之间的同系物数目差异很大。系统发育分析表明，Dikarya的祖先拥有多份cerato-platanins副本，这些副本在Ascomycota和Basidiomycota中排序不同，并且该基因家族可能在Basidiomycota中扩展。几乎所有的同源物都包含信号肽序列，而成熟蛋白的长度主要是105-134个氨基酸。在大多数同源物中，参与形成两个二硫键和特征序列（CSD或CSN）的四个半胱氨酸高度保守。这些结果表明在担子菌属中的cerato-platanin家族比在子囊菌中具有更高的多样性。

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