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首页> 外文期刊>Mycologia >Formation of conjugates from ciprofloxacin and norfloxacin in cultures of Trichoderma viride
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Formation of conjugates from ciprofloxacin and norfloxacin in cultures of Trichoderma viride

机译：在木霉菌培养物中由环丙沙星和诺氟沙星形成结合物

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摘要

The formation of conjugates from two antibacterial fluoroquinolone drugs, ciprofloxacin and norfloxacin, was observed in cultures of Trichoderma vi-ride that had been grown in sucrose-peptone broth and extracted 16 d after dosing with the drugs. Both conjugates were purified by high-performance liquid chromatography and found to be optically active. They were identified by mass and proton nuclear magnetic resonance spectra as 4-hydroxy-3-oxo-4-vinylcyclopent-1-enyl ciprofloxacin and 4-hydroxy-3-oxo-4-vinylcyclopent-1-enyl norfloxacin. The transformation of veterinary fluoroquinolones in the presence of fungi may have ecological significance.
机译：在蔗糖-蛋白p肉汤中生长的木霉vi-ride的培养物中观察到了由两种抗菌氟喹诺酮药物环丙沙星和诺氟沙星形成的缀合物，给药后16 d提取。两种结合物均通过高效液相色谱法纯化，并具有光学活性。通过质量和质子核磁共振谱将它们鉴定为4-羟基-3-氧代-4-乙烯基环戊-1-烯基环丙沙星和4-羟基-3-氧代-4-乙烯基环戊-1-烯基诺沙星。在真菌存在下兽用氟喹诺酮类药物的转化可能具有生态学意义。

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