Synthesis of 5-Phenylproline Derivatives with Antibacterial Activity

K. V. Kudryavtsev; M. Yu. Tsentalovich

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Synthesis of 5-Phenylproline Derivatives with Antibacterial Activity

机译：具有抗菌活性的5-苯基脯氨酸衍生物的合成

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Methyl esters of 5-phenylprolines with the vinylsulfonyl or cyano group in the 4-position of the pyrrolidine ring have been synthesized. X-ray crystallography shows that all substituents in the vinylsulfonyl derivatives are cis to each other. All compounds are inhibitors of Staphylococcus aureus sortase SrtA.

机译：合成了在吡咯烷环的4-位带有乙烯基磺酰基或氰基的5-苯基脯氨酸的甲酯。 X射线晶体学表明，乙烯基磺酰基衍生物中的所有取代基彼此都是顺式的。所有化合物均为金黄色葡萄球菌分选酶SrtA的抑制剂。

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《Moscow University Chemistry Bulletin》 |2007年第5期|共5页
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K. V. Kudryavtsev; M. Yu. Tsentalovich;
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Synthesis of 5-Phenylproline Derivatives with Antibacterial Activity

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