Computational design of an RNA hexagonal nanoring and an RNA nanotube

Yingling YG; Shapiro BA

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Computational design of an RNA hexagonal nanoring and an RNA nanotube

机译：RNA六角形纳米环和RNA纳米管的计算设计

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The combination of computer modeling, RNA structure versatility, and siRNA function can be efficiently used to design an all-RNA nanoparticle capable of siRNA delivery. Here, we present a computational design of an RNA nanoring and a nanotube. An RNA nanoring consists of six simple linear building blocks that are assembled together via known noncovalent loop-loop contacts based on RNAI/RNAII inverse sequences. The helical sequences of the building blocks can include siRNAs for drug delivery.

机译：计算机建模，RNA结构的多功能性和siRNA功能的组合可以有效地用于设计能够进行siRNA递送的全RNA纳米颗粒。在这里，我们介绍了RNA纳米环和纳米管的计算设计。 RNA纳米环由六个简单的线性构件组成，这些构件通过基于RNAI / RNAII反向序列的已知非共价环-环接触而组装在一起。构件的螺旋序列可包括用于药物递送的siRNA。

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《Nano letters》 |2007年第8期|共7页
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Yingling YG; Shapiro BA;
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正文语种 eng
中图分类特种结构材料;
关键词
LOOP-LOOP COMPLEX; MOLECULAR-DYNAMICS; ROM PROTEIN; DELIVERY; CANCER; DNA; NANOSTRUCTURES; NANOTECHNOLOGY; CONSTRUCTION; NANOPARTICLE;

机译：环状复合物;分子动力学;蛋白质;递送;癌症;DNA;纳米结构;纳米技术;结构;纳米;

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专利

1. Computational design of an RNA hexagonal nanoring and an RNA nanotube [J] . Yingling YG, Shapiro BA Nano letters . 2007,第8期

机译：RNA六角形纳米环和RNA纳米管的计算设计
2. Computational Characterization of a Photonic Crystal Cantilever Sensor Using a Hexagonal Dual-Nanoring-Based Channel Drop Filter [J] . Li B., Hsiao F.-L., Lee C. Nanotechnology, IEEE Transactions on . 2011,第4期

机译：基于六角形双通道的通道降滤器的光子晶体悬臂传感器的计算表征
3. Nanophotonic biosensors using hexagonal nanoring resonators: computational study [J] . Fu-Li Hsiao, Chengkuo Lee Journal of microanolithography, MEMS, and MOEMS . 2011,第1期

机译：使用六角形纳米环谐振器的纳米光子生物传感器：计算研究
4. Engineered RNA Nanorings for Efficient Delivery of siRNA [C] . Alexey Koyfman, Kirill Afonin, Angelica Martins, Society for Biomaterials annual meeting and exposition . 2015

机译：工程化的RNA纳米环可有效递送siRNA
5. Bacterial Microleakage of Different Sealing Materials in Access Channels of Internal and External Hexagonal Implants. [D] . Davis, Jameson. 2017

机译：内部和外部六角形植入物进入通道中不同密封材料的细菌微渗漏。
6. Design of Potential RNAi (miRNA and siRNA) Molecules for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Gene Silencing by Computational Method [O] . Suza Mohammad Nur, Md. Anayet Hasan, Mohammad Al Amin, -1

机译：计算方法设计的中东呼吸系统综合症冠状病毒（MERS-CoV）基因沉默的潜在RNAi（miRNA和siRNA）分子。
7. Phase transitions in hexagonal, graphene-like lattice sheets and nanotubes under the influence of external conditions [O] . Ebert, D., Klimenko, K. G., Kolmakov, P. B., 2016

机译：六角形，石墨烯状晶格片和相变的相变纳米管受外界条件的影响

Computational design of an RNA hexagonal nanoring and an RNA nanotube

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