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首页> 外文期刊>Nanotechnology >Carbon-nanotube-assisted high loading and controlled release of polyoxometalates in biodegradable multilayer thin films
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Carbon-nanotube-assisted high loading and controlled release of polyoxometalates in biodegradable multilayer thin films

机译：碳纳米管辅助可生物降解多层薄膜中多金属氧酸盐的高负载和控释

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摘要

Carbon nanotubes loaded with peptides, proteins and drugs can translocate across the cell membrane. This big advantage has attracted increasing attention to design a novel delivery system using nanotubes. Polyoxometalate (POM) is a promising antitumor drug and it shows a very strong interaction with carbon nanotube surfaces. In this paper, a novel complex of POM-modified single-walled carbon nanotubes (SWNTs) and chitosan was fabricated through a layer-by-layer self-assembly process. With the addition of SWNTs, the loading of POM in this thin film was doubled in the high ionic strength. The initial burst release of POMs in the (POM/chitosan)_n thin film was suppressed in the (POM-SWNT/chitosan)_n thin film. Also the instability of POMs in a physiologically relevant pH environment was overcome. The strong interaction between POMs and SWNTs was believed to be the determinant factor in the higher loading and prolonged release of POMs in (POM-SWNT/chitosan)_n thin films.
机译：载有肽，蛋白质和药物的碳纳米管可以在细胞膜上移位。这个巨大的优势吸引了越来越多的人关注使用纳米管设计新颖的递送系统。多金属氧酸盐（POM）是一种很有前途的抗肿瘤药物，它与碳纳米管表面表现出非常强的相互作用。本文通过逐层自组装工艺制备了一种新型的POM修饰的单壁碳纳米管（SWNT）与壳聚糖的复合物。通过添加SWNT，高离子强度使该薄膜中POM的含量增加了一倍。在（POM-SWNT /壳聚糖）_n薄膜中，POM /（壳聚糖）_n薄膜中POM的初始爆发释放得到抑制。还克服了在生理相关的pH环境中POM的不稳定性。 POM和SWNT之间的强相互作用被认为是（POM-SWNT /壳聚糖）_n薄膜中POM的较高负载和延长释放的决定因素。

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