...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Microbes and infection >IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection
【24h】

IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection

机译：IFN-γ诱导蛋白10和pentraxin 3血浆水平是监测结核分枝杆菌感染中炎症和疾病活性的工具

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

IFN-gamma-inducible protein 10 (IP-10/CXCL10) is a chemokine involved in delayed-type hypersensitivity and attraction of monocytes and activated T lymphocytes at inflammatory foci, whereas pentraxin 3 (PTX3) is part of the innate immune response. In the Republic of Guinea, 220 newly diagnosed, HIV-negative, pulmonary tuberculosis (TB) patients were studied together with 220 healthy household controls and 220 community controls. CXCL10 and PTX3 blood levels were assessed by ELISA at diagnosis, after 2 months and at the end of treatment. In untreated patients, both CXCL 10 and PTX3 levels were higher (P < 0.0001) than in controls, although household controls had higher (P < 0.0001) CXCL10 and PTX3 levels than community controls, but lower (P < 0.0001) than those of patients. At the end of treatment, 186 cured patients showed reduction (P < 0.0001) in both CXCL10 and PTX3 levels. In 34 patients with treatment failure, both CXCL10 and PTX3 levels increased further. In five previously healthy households who developed TB during the follow-up and in two patients who relapsed after treatment, a remarkable increase in both CXCL10 and PTX3 plasma levels was observed. Active TB is associated with increased CXCL 10 and PTX3 levels in the plasma. Although not specific for TB, measurement of these proteins may help the monitoring of disease activity and efficacy of therapy. (C) 2004 Elsevier SAS. All rights reserved.
机译：IFN-γ诱导蛋白10（IP-10 / CXCL10）是一种趋化因子，参与延迟型超敏反应以及在炎症灶处吸引单核细胞和活化T淋巴细胞，而pentraxin 3（PTX3）是先天性免疫反应的一部分。在几内亚共和国，对220名新诊断为HIV阴性的肺结核（TB）患者以及220名健康的家庭对照和220名社区对照进行了研究。在诊断时，治疗2个月后和治疗结束时，通过ELISA评估CXCL10和PTX3血液水平。在未经治疗的患者中，CXCL 10和PTX3水平均高于对照组（P <0.0001），尽管家庭对照组的CXCL10和PTX3水平高于社区对照组，但低于患者（P <0.0001） 。在治疗结束时，有186例治愈的患者CXCL10和PTX3水平均降低（P <0.0001）。在34例治疗失败的患者中，CXCL10和PTX3水平均进一步升高。在随访期间出现结核病的五个先前健康的家庭中，以及在治疗后复发的两名患者中，CXCL10和PTX3血浆水平均显着升高。活动性结核病与血浆中CXCL 10和PTX3水平升高有关。尽管对结核病不是特异的，但是对这些蛋白质的测量可能有助于监测疾病的活性和治疗效果。 （C）2004 Elsevier SAS。版权所有。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号