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首页> 外文期刊>Microbes and infection >Burkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis
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Burkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis

机译：基于脉冲场凝胶电泳的伯克霍尔德菌假性Mallei菌株类型不能确定类li虫病的疾病表现

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摘要

Melioidosis, the infection due to Burkholderia pseudomallei, may present with a spectrum of severity and may affect any site in the body. Differential strain virulence and tropism suggested by previous studies would have implications for virulence and vaccine work. We explored clinical correlations using pulsed-field gel electrophoresis (PFGE) typing in a well-characterised clinical collection. Two methods of analysis were used based on band-based similarity values: first, a conventional cluster analysis formed by the unweighted paired group mean analysis, and second, an analysis of the distribution of the "within-group" and "between-group" Dice coefficient. Clinical isolates from 114 cases of melioidosis occurring in the Northern Territory, Australia were studied; 71 strain types were defined with a Simpson's index of 0.91. No correlation was found between strain type and disease severity or site of melioidosis on presentation, with no differences in similarity values found when comparing within and between-groups. In particular, isolates from patients with neurological melioidosis were not clustered. There was evidence of geographical localisation. This study suggests that the variation in strain type may not be as important as host and environmental factors in determining the pattern of disease. (C) 2004 Elsevier SAS. All rights reserved.
机译：拟南芥（类鼻疽伯克霍尔德氏菌引起的感染）可能具有严重程度，并可能影响体内的任何部位。以前的研究表明，菌株的毒力和向性差异将对毒力和疫苗工作产生影响。我们探索了临床相关性，使用脉冲场凝胶电泳（PFGE）在一个特征明确的临床集合中进行分型。基于基于带的相似性值，使用了两种分析方法：第一，由未加权的成对均值分析形成的常规聚类分析，第二，对“组内”和“组间”分布的分析骰子系数。研究了澳大利亚北部地区发生的114例类鼻疽病的临床分离株。定义了71种菌株，辛普森指数为0.91。在呈现时，在菌株类型与疾病严重程度或类胡突病部位之间未发现相关性，在组内和组间比较时发现相似性值无差异。特别是来自神经系统类瘤病患者的分离株未聚类。有地理定位的证据。这项研究表明，在确定疾病模式时，菌株类型的变异可能不如宿主和环境因素那么重要。 （C）2004 Elsevier SAS。版权所有。

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