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Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers

机译：由电纺聚乙烯吡咯烷酮超细纤维制备的口服速溶药物输送膜

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摘要

Oral fast-dissolving drug delivery membranes (FDMs) for poorly water-soluble drugs were prepared via electrospinning technology with ibuprofen as the model drug and polyvinylpyrrolidone (PVP) K30 as the filament-forming polymer and drug carrier. Results from differential scanning calorimetry, x-ray diffraction, and morphological observations demonstrated that ibuprofen was distributed in the ultrafine fibers in the form of nanosolid dispersions and the physical status of drug was an amorphous or molecular form, different from that of the pure drug and a physical mixture of PVP and ibuprofen. Fourier-transform infrared spectroscopy results illustrated that the main interactions between PVP and ibuprofen were mediated through hydrogen bonding. Pharmacotechnical tests showed that FDMs with different drug contents had almost the same wetting and disintegrating times, about 15 and 8 s, respectively, but significantly different drug dissolution rates due to the different physical status of the drug and the different drug-release-controlled mechanisms. 84.9% and 58.7% of ibuprofen was released in the first 20 s for FDMs with a drug-to-PVP ratio of 1: 4 and 1: 2, respectively. Electrospun ultrafine fibers have the potential to be used as solid dispersions to improve the dissolution profiles of poorly water-soluble drugs or as oral fast disintegrating drug delivery systems.
机译：通过电纺技术，以布洛芬为模型药物，聚乙烯吡咯烷酮（PVP）K30为长丝形成聚合物和药物载体，通过静电纺丝技术制备了水溶性差的口服速溶药物输送膜。差示扫描量热法，X射线衍射和形态学观察结果表明，布洛芬以纳米固体分散体的形式分布在超细纤维中，药物的物理状态为无定形或分子形式，与纯药物和PVP和布洛芬的物理混合物。傅里叶变换红外光谱结果表明，PVP和布洛芬之间的主要相互作用是通过氢键介导的。药理学测试表明，具有不同药物含量的FDM的润湿和崩解时间几乎相同，分别约为15和8 s，但是由于药物的不同物理状态和不同的药物释放控制机制，其药物溶出速率存在显着差异。对于FDM，布洛芬在最初20 s释放了84.9％和58.7％，药物与PVP的比例分别为1：4和1：2。电纺超细纤维有潜力用作固体分散体，以改善水溶性差的药物的溶出度，或用作口服快速崩解药物的输送系统。

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