Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity

Chen C; Peng J; Xia HS; Wu QS; Zeng LB; Xu H; Tang HW; Zhang ZL; Zhu XB; Pang DW; Li Y

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Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity

机译：基于量子点的HER2和ER免疫荧光成像为乳腺癌异质性提供了新见解

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Breast cancer (BC) is a heterogeneous tumor, and better understanding of its heterogeneity is essential to improving treatment effect. Quantum dot (QD)-based immunofluorescent nanotechnology (QD-IHC) for molecular pathology has potential advantages in delineating tumor heterogeneity. This potential is explored in this paper by QD-IHC imaging of HER2 and ER. BC heterogeneity can be displayed more clearly and sensitively by QD-IHC than conventional IHC in BC tissue microarrays. Furthermore, the simultaneous imaging of ER and HER2 might help understand their interactions during the process of evolution of heterogeneous BC.

机译：乳腺癌（BC）是一种异质性肿瘤，更好地了解其异质性对于提高治疗效果至关重要。用于分子病理学的基于量子点（QD）的免疫荧光纳米技术（QD-IHC）在描述肿瘤异质性方面具有潜在优势。本文通过HER2和ER的QD-IHC成像探索了这种潜力。 QD-IHC可以比BC组织微阵列中的常规IHC更清楚，更敏感地显示BC异质性。此外，ER和HER2的同时成像可能有助于了解异质BC进化过程中的相互作用。

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来源
《Nanotechnology》 |2010年第9期|共6页
作者
Chen C; Peng J; Xia HS; Wu QS; Zeng LB; Xu H; Tang HW; Zhang ZL; Zhu XB; Pang DW; Li Y;
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正文语种 eng
中图分类特种结构材料;
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ESTROGEN-RECEPTOR; QUANTITATIVE IMMUNOHISTOCHEMISTRY; HEPATOCELLULAR-CARCINOMA; BIOLOGICAL APPLICATIONS; CLINICAL-IMPLICATIONS; TUMOR HETEROGENEITY; TISSUE MICROARRAYS; HORMONE-RECEPTORS; THERAPY; RESISTANCE;

机译：雌激素受体;定量免疫组织化学;肝细胞癌;生物学应用;临床意义;肿瘤异质性;组织微阵列;激素受体;治疗;抗药性;

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1. Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity [J] . Chen C, Peng J, Xia HS, Nanotechnology . 2010,第9期

机译：基于量子点的HER2和ER免疫荧光成像为乳腺癌异质性提供了新见解
2. ER+/HER2(+) Breast Cancer Has Different Metastatic Patterns and Better Survival Than ER-/HER2(+) Breast Cancer [J] . Arciero Cletus A., Guo Yi, Jiang Renjian, Clinical breast cancer . 2019,第4期

机译：ER + / HER2（+）乳腺癌具有不同的转移模式和比ER-/ HER2（+）乳腺癌更好的存活
3. Quantum dot-based immunofluorescent imaging of Ki67 and identification of prognostic value in HER2-positive (non-luminal) breast cancer [J] . Jin-Zhong Sun, Chuang Chen, Guan Jiang, International Journal of Nanomedicine . 2014,第1期

机译：Ki67的基于量子点的免疫荧光成像和HER2阳性（非管腔）乳腺癌的预后价值鉴定
4. Quantum-dot-based immunofluorescent imaging of Cancer Marker P53 Detection in Breast Cancer [C] . WANYING XING, QIANG LI, XING REN, International Conference on Environment, Materials, Chemistry and Power Electronics . 2016

机译：乳腺癌中癌症标志物P53检测量子 - 点的免疫荧光成像
5. TGF-B signaling pathway, ER-alpha and the heterogeneity of breast cancer risk among Hispanic and non-Hispanic white women. [D] . Boone, Stephanie Denkhoff. 2013

机译：西班牙裔和非西班牙裔白人女性的TGF-B信号通路，ER-α和乳腺癌风险的异质性。
6. The prognostic value of quantitative analysis of CCL5 and collagen IV in luminal B (HER2−) subtype breast cancer by quantum-dot-based molecular imaging [O] . Yong-yun Zhu, Chuang Chen, Juan-Juan Li, 2018

机译：基于量子点的分子成像定量分析管腔B（HER2-）亚型乳腺癌中CCL5和胶原蛋白IV的预后价值
7. Quantum-dot-based immunofluorescent imaging of Cancer Marker P53 Detection in Breast Cancer [O] . Wanying Xing, Qiang Li, Xing Ren, 2016

机译：乳腺癌中癌症标志物P53检测量子 - 点的免疫荧光成像

Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity

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