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Probing electrical properties of oriented DNA by conducting atomic force microscopy

机译：通过原子力显微镜探测定向DNA的电学性质

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摘要

Different methods have been applied for the stretching of DNA molecules on chemically functionalized surfaces by various modified reagents, i.e. 3-aminopropyltriethanoxysilane or polylysine on mica and 2-mercaptoethylamine on Au(111)/mica by a moving interface technique, magnesium cation (Mg~(2+)) on mica by a spin-stretching method and DNA on an atomic-level flat mica by a free-flowing method. The long #lambda#-DNA molecule is well elongated using the moving interface technique. The DNA molecule array density can be controlled by the change of surface charge density and the DNA concentration. On the other hand, the novel free-flowing method is very useful for the alignment of short polynucleotide molecules. Shadow-mask evaporation has been used to fabricate a gold electrode contacted electrically to the oriented DNA molecules. The intrinsic electrical properties of individual DNA molecules are directly measured using a conducting probe atomic force microscope equipped with a gold-coated conductive tip. The DNA molecule is considered as a promising molecular wire.
机译：通过各种改性试剂，通过移动界面技术，镁阳离子（Mg〜 （2+））在云母上通过自旋拉伸方法进行合成，而DNA在原子级平面云母上通过自由流动方法进行转化。使用移动界面技术可以很好地延长长的＃lambda＃-DNA分子。 DNA分子阵列的密度可以通过表面电荷密度和DNA浓度的变化来控制。另一方面，新颖的自由流动方法对于短多核苷酸分子的比对非常有用。荫罩蒸发已被用于制造与定向DNA分子电接触的金电极。使用配备有镀金导电尖端的导电探针原子力显微镜直接测量单个DNA分子的固有电学性质。 DNA分子被认为是有前途的分子丝。

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