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首页> 外文期刊>Nature reviews. Clinical oncology >Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
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Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?

机译：免疫疗法和立体定向消融放射疗法（ISABR）：一种治疗方法？

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Conventional radiotherapy, in addition to its well-established tumoricidal effects, can also activate the host immune system. Radiation therapy modulates tumour phenotypes, enhances antigen presentation and tumour immunogenicity, increases production of cytokines and alters the tumour microenvironment, enabling destruction of the tumour by the immune system. Investigating the combination of radiotherapy with immunotherapeutic agents, which also promote the host antitumour immune response is, therefore, a logical progression. As the spectrum of clinical use of stereotactic radiotherapy continues to broaden, the question arose as to whether the ablative radiation doses used can also stimulate immune responses and, if so, whether we can amplify these effects by combining immunotherapy and stereotactic ablative radiotherapy (SABR). In this Perspectives article, we explore the preclinical and clinical evidence supporting activation of the immune system following SABR. We then examine studies that provide data on the effectiveness of combining these two techniques-immunotherapy and SABR-in an approach that we have termed 'ISABR'. Lastly, we provide general guiding principles for the development of future clinical trials to investigate the efficacy of ISABR in the hope of generating further interest in these exciting developments.
机译：常规放射疗法除了具有公认的杀肿瘤作用外，还可以激活宿主免疫系统。放射疗法可调节肿瘤表型，增强抗原呈递和肿瘤免疫原性，增加细胞因子的产生并改变肿瘤微环境，从而使免疫系统能够破坏肿瘤。因此，研究放射疗法与免疫治疗剂的组合也可以促进宿主的抗肿瘤免疫反应，这是合乎逻辑的进展。随着立体定向放射疗法临床应用范围的不断扩大，出现了一个问题，即所用的消融放射剂量是否还能刺激免疫反应，如果可以，我们是否可以通过将免疫疗法和立体定向消融放射疗法（SABR）结合使用来扩大这些效应。在本文中，我们探讨了SABR后支持免疫系统激活的临床前和临床证据。然后，我们研究了提供有关结合这两种技术（免疫治疗和SABR）的有效性的数据的研究，这种方法被我们称为“ ISABR”。最后，我们为将来的临床试验开发提供一般指导原则，以研究ISABR的功效，以期引起人们对这些令人振奋的进展的兴趣。

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