Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.

Bishop BL; Duncan MJ; Song J; Li G; Zaas D; Abraham SN

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Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.

机译：循环AMP调节感染的膀胱上皮细胞对大肠杆菌的胞吐作用。

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The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) circumvents the bladder barrier by harboring in these Rab27b/CD63-positive and cAMP-regulatable fusiform vesicles within bladder epithelial cells (BECs). Incorporation of UPEC into BEC fusiform compartments enabled bacteria to escape elimination during voiding and to re-emerge in the urine as the bladder distended. Notably, treatment of UPEC-infected mice with a drug that increases intracellular cAMP and induces exocytosis of fusiform vesicles reduced the number of intracellular E. coli.

机译：浅表膀胱上皮是尿液的有力屏障，并且还充当膀胱体积的调节器，这是通过在膀胱扩张期间专用梭形囊泡的顶端胞吐作用实现的。我们报告类型1纤维化尿路致病性大肠杆菌（UPEC）通过在膀胱上皮细胞（BECs）内这些Rab27b / CD63阳性和cAMP可调节梭形囊泡中掩藏来绕开膀胱屏障。将UPEC掺入BEC梭形隔室可使细菌在排尿过程中逃脱消除，并在膀胱扩张时重新出现在尿液中。值得注意的是，用增加细胞内cAMP并诱导梭形囊泡胞吐的药物治疗UPEC感染的小鼠减少了细胞内大肠杆菌的数量。

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《Nature medicine》 |2007年第5期|共6页
作者
Bishop BL; Duncan MJ; Song J; Li G; Zaas D; Abraham SN;
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正文语种 eng
中图分类医药、卫生;
关键词
Bladder; Exocytosis; Escherichia coli; Epithelial Cells; 膀胱; 胞吐作用; 大肠杆菌; 上皮细胞;

机译：Bladder;Exocytosis;Escherichia coli;Epithelial Cells;膀胱;胞吐作用;大肠杆菌;上皮细胞;

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专利

1. Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. [J] . Bishop BL, Duncan MJ, Song J, Nature medicine . 2007,第5期

机译：循环AMP调节感染的膀胱上皮细胞对大肠杆菌的胞吐作用。
2. Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. [J] . Gupta K, Chou MY, Howell A, The Journal of Urology . 2007,第6期

机译：蔓越莓产品可抑制p纤维化大肠杆菌对原代培养的膀胱和阴道上皮细胞的粘附。
3. Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli [J] . DemirelI., S?veS., KruseR., APMIS: Acta Pathologica, Microbiologica et Immunologica Scandinavica . 2013,第2期

机译：细胞因子信号转导抑制因子3（SOCS3）的表达在泌尿致病性大肠杆菌感染的人膀胱上皮细胞中的表达
4. cis-9, trans-11-Conjugated Linoleic Acid Exerts an Anti-inflammatory Effect in Bovine Mammary Epithelial Cells after Escherichia coli Stimulation through NF-κB Signaling Pathway [C] . Nana Ma, Guangjun Chang, Jie Huang, The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

机译：CIS-9，通过NF-κB信号通路在大肠杆菌刺激后牛乳液上皮细胞对牛乳液上皮细胞的抗炎作用施加抗炎作用
5. Invasion of uropathogenic Escherichia coli into human bladder epithelial cells: Examination of novel host-pathogen interactions. [D] . Martinez, Juan Jose. 2001

机译：尿路致病性大肠杆菌侵袭人膀胱上皮细胞：新型宿主-病原体相互作用的检查。
6. Phospholipase activity in bacteriophage-infected Escherichia coli. III. Phopholipase A involvement in lysis of T4-infected cells. [O] . K L Hardaway, M V Maten, C S Buller 1975

机译：噬菌体感染的大肠杆菌中的磷脂酶活性。三磷脂酶A参与T4感染细胞的裂解。
7. The hemorrhagic coli pilus (HCP) of Escherichia coli O157:H7 is an inducer of proinflammatory cytokine secretion in intestinal epithelial cells. [O] . Maria A Ledesma, Sara A Ochoa, Ariadnna Cruz, 2010

机译：大肠杆菌O157：H7的出血性大肠杆菌（HCp）是肠上皮细胞中促炎细胞因子分泌的诱导物。

Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.

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