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首页> 外文期刊>Biochemistry >Sulfated Galactofucan from Lobophora variegata: Anticoagulant and Anti-inflammatory Properties
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Sulfated Galactofucan from Lobophora variegata: Anticoagulant and Anti-inflammatory Properties

机译：变叶狼蛛的硫酸化半乳聚糖：抗凝血和抗炎特性

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摘要

Sulfated polysaccharides (fucans and fucoidans) from brown algae show several biological activities, including anticoagulant and anti-inflammatory activities. We have extracted a sulfated heterofucan from the brown seaweed Lobophora variegata by proteolytic digestion, followed by acetone fractionation, molecular sieving, and ion-exchange chromatography. Chemical analyses and ~(13)C-NMR and IR spectroscopy showed that this fucoidan is composed of fucose, galactose, and sulfate at molar ratios of 1: 3 : 2. We compared the anticoagulant activity of L. variegata fucoidan with those of a commercial sulfated polysaccharide (also named fucoidan) from Fucus vesiculosus and heparin. The experimental inflammation models utilized in this work revealed that fucoidan from L. variegata inhibits leukocyte migration to the inflammation site. Ear swelling caused by croton oil was also inhibited when sulfated polysaccharides from F. vesiculosus and L. variegata were used. The precise mechanism of different action between homo- and heterofucans is not clear; nevertheless, the polysaccharides studied here may have therapeutic potential in inflammatory disorders.
机译：褐藻中的硫酸化多糖（岩藻聚糖和岩藻依聚糖）具有多种生物学活性，包括抗凝和抗炎活性。我们通过蛋白水解消化，然后通过丙酮分级分离，分子筛和离子交换色谱法，从棕色海藻Lobophora variegata中提取了硫酸化的杂岩藻糖。化学分析和〜（13）C-NMR和IR光谱表明，该岩藻依聚糖由岩藻糖，半乳糖和硫酸盐组成，摩尔比为1：3：2。来自水榕和肝素的市售硫酸化多糖（也称为岩藻依聚糖）。在这项工作中使用的实验性炎症模型表明，来自杂色乳杆菌的岩藻依聚糖具有抑制白细胞向炎症部位迁移的作用。当使用来自豌豆假单胞菌和杂色镰刀菌的硫酸化多糖时，也抑制了由巴豆油引起的耳朵肿胀。同型和异型岩藻糖之间不同作用的确切机制尚不清楚。然而，本文研究的多糖可能在炎性疾病中具有治疗潜力。

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