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首页> 外文期刊>Natural product communications >PSY-1, a Taxus chinensis var. mairei Extract, Inhibits Cancer Cell Metastasis by Interfering with MMPs
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PSY-1, a Taxus chinensis var. mairei Extract, Inhibits Cancer Cell Metastasis by Interfering with MMPs

机译：PSY-1，红豆杉变种。 mairei提取物，通过干扰MMP抑制癌细胞转移

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Cancer is the most common disease worldwide, with death often occurring as a result of metastasis. Thus, interfering with metastasis has been regarded as a promising strategy to improve the current cancer treatments. However, exploration and development of novel anti-metastatic agents remains a major challenge. Recent evidence indicated that a polysaccharide isolated from Taxus yunnanensis suppressed tumor cells proliferation. With the objective of seeking bioactive extracts, we had previously isolated, purified and characterized a complex, water-soluble polysaccharides, PSY-1, from the leaves of Taxus chinensis var. mairei, and identified its anti-neoplastic effects. In this study, we focused on the effects of PSY-1 on cancer metastasis and its mechanism(s). The results illustrated that PSY-1 effectively suppressed the migration and invasion ability of the melanoma cancer cell line B16-F10, caused down-regulation of MMP-2 and MMP-9, and that the NF-kB pathway was involved in the anti-metastatic effects imposed by PSY-1.
机译：癌症是全世界最常见的疾病，转移通常会导致死亡。因此，干扰转移已被认为是改善当前癌症治疗的有希望的策略。然而，新型抗转移剂的探索和开发仍然是主要挑战。最近的证据表明，从云南红豆杉分离出的多糖抑制肿瘤细胞的增殖。为了寻找具有生物活性的提取物，我们以前从红豆杉的叶片中分离，纯化和鉴定了复杂的水溶性多糖PSY-1。 mairei，并确定了其抗肿瘤作用。在这项研究中，我们集中于PSY-1对癌症转移的影响及其机制。结果表明PSY-1有效抑制黑素瘤癌细胞系B16-F10的迁移和侵袭能力，引起MMP-2和MMP-9的下调，而NF-kB通路参与了抗PSY-1施加的转移作用。

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