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首页> 外文期刊>Natural product communications >Effects on MC3T3-E1 Cells and In silico Toxicological Study of Two 6-(Propan-2-yl)-4-methyl-morpholine-2,5-diones
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Effects on MC3T3-E1 Cells and In silico Toxicological Study of Two 6-(Propan-2-yl)-4-methyl-morpholine-2,5-diones

机译：两种6-（丙-2-基）-4-甲基-吗啉-2,5-二酮对MC3T3-E1细胞的影响和计算机毒理学研究

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摘要

Recently, we found that two cyclodidepsipeptides, 3,6-di-(propan-2-yl)-4-methyl-morpholine-2,5-dione (1) and 3-(2-methylpropyl)-6-(propan-2-yl)-4-methylmorpholine-2,5-dione (2), are excellent inhibitors of xanthine oxidase. In order to obtain more information about the toxicological potential of compounds 1 and 2 on bone cells, the current study was designed to evaluate the effect of these compounds on viability and proliferation of MC3T3-E1 cells. Compound 1 showed neither cytotoxic nor stimulatory effect on cell viability, while compound 2 showed a slight stimulatory effect on cell viability. Both studied compounds showed slight stimulatory effects on proliferation of MC3T3-E1 cells, in a dose dependent manner. Additionally, an in silico toxicological study of compounds 1 and 2 was performed, and the results indicate that they have a good probability of safe biological intake.
机译：最近，我们发现了两个环二肽肽：3,6-二-（丙-2-基）-4-甲基吗啉-2,5-二酮（1）和3-（2-甲基丙基）-6-（丙- 2-yl）-4-methylmorpholine-2,5-dione（2）是黄嘌呤氧化酶的优异抑制剂。为了获得有关化合物1和2对骨细胞的毒理学潜力的更多信息，当前的研究旨在评估这些化合物对MC3T3-E1细胞活力和增殖的影响。化合物1对细胞活力既没有细胞毒性也没有刺激作用，而化合物2对细胞活力没有轻微的刺激作用。两种研究的化合物均以剂量依赖性方式显示出对MC3T3-E1细胞增殖的轻微刺激作用。另外，对化合物1和2进行了计算机毒理学研究，结果表明它们具有安全的生物摄取的良好可能性。

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